Ethanone, 1-(4-chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-, hydrochloride (1:1)
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![Ethanone, 1-(4-chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-, hydrochloride (1:1) structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220811/5c1f7496567f49a988fc58f4a9002108.png "Ethanone, 1-(4-chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-, hydrochloride (1:1)")
Ethanone, 1-(4-chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-, hydrochloride (1:1)
structure -
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CAS No:
26786-32-3
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Formula:
C26H27ClN2O.ClH
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Chemical Name:
Ethanone, 1-(4-chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-, hydrochloride (1:1)
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Synonyms:
Ethanone,1-(4-chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-,hydrochloride (1:1);Acetophenone,4′-chloro-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-,monohydrochloride;Ethanone,1-(4-chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-,monohydrochloride;Lopramine hydrochloride;Leo 640 hydrochloride;Lofepramine hydrochloride;Gamonil;Tymelyt;WHR 2908A;Timelit;Gamanil
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CAS No:
Description
Lofepramine hydrochloride is a hydrochloride. It has a role as an antidepressant. It contains a lofepramine.|A psychotropic IMIPRAMINE derivative that acts as a tricyclic antidepressant and possesses few anticholinergic properties. It is metabolized to DESIPRAMINE.
Ethanone, 1-(4-chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-, hydrochloride (1:1) Basic Attributes
455.41900
454.1578689 g/mol
248-002-2
Z24K96F991
DTXSID9047833
Characteristics
23.55000
6.64850
off-white solid
152-154 °C
575ºC
301.6ºC
2-8ºC
3.17E-13mmHg at 25°C
Safety Information
P210; P280; P302 + P352 + P312; P304 + P340 + P312; P370 + P378; P403 + P235
H225; H290; H301 + H311 + H331; H370
|Warning|H302 (97.44%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P273, P301+P312, P304+P340, P312, P330, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system. (See all compounds classified as Antidepressive Agents, Tricyclic.)
Deftan
Computed Properties
Molecular Weight:455.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:454.1578689
Monoisotopic Mass:454.1578689
Topological Polar Surface Area:23.6
Heavy Atom Count:31
Complexity:523
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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Latest News on Ethanone, 1-(4-chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-, hydrochloride (1:1)
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