3-(Aminocarbonyl)-1(4H)-pyridineacetamide
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3-(Aminocarbonyl)-1(4H)-pyridineacetamide
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CAS No:
64881-21-6
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Formula:
C8H11N3O2
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Chemical Name:
3-(Aminocarbonyl)-1(4H)-pyridineacetamide
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Synonyms:
1(4H)-Pyridineacetamide,3-(aminocarbonyl)-;3-(Aminocarbonyl)-1(4H)-pyridineacetamide;1-Carbamoylmethyl-1,4-dihydronicotinamide;EP 0152R;Caricotamide;1-(Carbamoylmethyl)-1,4-dihydropyridine-3-carboxamide;1-(2-Amino-2-oxoethyl)-4H-pyridine-3-carboxamide
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CAS No:
Description
Caricotamide is a synthetic co-substrate that activates the human endogenous enzyme NRH:quinone oxidoreductase 2 (NQO2) with potential chemoadjuvant activity. When caricotamide is administered simultaneously with the prodrug tretazicar, NQO2 converts tretazicar to the bifunctional alkylating agent dinitrobenzamide, which is capable of forming a high degree of DNA interstrand cross-links, resulting in the inhibition of DNA replication and the induction of apoptosis. NQO2 has been found to be over-expressed in cancers such as hepatocellular carcinoma (HCC), colorectal and ovarian cancers.
3-(Aminocarbonyl)-1(4H)-pyridineacetamide Basic Attributes
181.19200
181.19
613-723-7
MC09H30MFS
717765
DTXSID80215170
C79915
2933399090
Computed Properties
Molecular Weight:181.19
XLogP3:-1.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:181.085126602
Monoisotopic Mass:181.085126602
Topological Polar Surface Area:89.4
Heavy Atom Count:13
Complexity:294
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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