4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-3-chlorophenol
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![4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-3-chlorophenol structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220811/692b2b3a73814b85888b7d405c19ad49.png "4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-3-chlorophenol")
4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-3-chlorophenol
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CAS No:
134865-33-1
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Formula:
C12H18ClNO2
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Chemical Name:
4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-3-chlorophenol
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Synonyms:
Meluadrine [INN]; Meluadrine;
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CAS No:
Description
Meluadrine is a beta-adrenergic receptor agonist with tocolytic activity. Meluadrine binds to and activates beta-2 adrenergic receptors of myometrial smooth muscle in the uterus, thereby activates adenyl cyclase, an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP levels leads to a reduction in intracellular calcium concentration, thereby causes smooth muscle relaxation and decreases the intensity of uterine contractions.
4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-3-chlorophenol Basic Attributes
243.73000
243.1026065
FYC8314117
DTXSID8048810
C66083
Computed Properties
Molecular Weight:243.73
XLogP3:1.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:243.1026065
Monoisotopic Mass:243.1026065
Topological Polar Surface Area:52.5
Heavy Atom Count:16
Complexity:218
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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