Vanoxerine dihydrochloride
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Vanoxerine dihydrochloride
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CAS No:
67469-78-7
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Formula:
C28H32F2N2O.2ClH
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Chemical Name:
Vanoxerine dihydrochloride
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Synonyms:
Piperazine,1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)-,hydrochloride (1:2);Piperazine,1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)-,dihydrochloride;GBR 12909;I 893;Vanoxerine dihydrochloride;1-(2-(Bis(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine dihydrochloride;110872-73-6
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CAS No:
Description
Vanoxerine dihydrochloride is a hydrochloride salt that is obtained by reaction of vanoxerine with two equivalents of hydrogen chloride. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration. It has a role as a dopamine uptake inhibitor. It contains a vanoxerine(2+).
Drug Information
Drugs that block the transport of DOPAMINE into axon terminals or into storage vesicles within terminals. Most of the ADRENERGIC UPTAKE INHIBITORS also inhibit dopamine uptake. (See all compounds classified as Dopamine Uptake Inhibitors.)
1-(2 (bis(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine
Computed Properties
Molecular Weight:523.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:10
Exact Mass:522.2016254
Monoisotopic Mass:522.2016254
Topological Polar Surface Area:15.7
Heavy Atom Count:35
Complexity:498
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
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