N-[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide
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N-[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide
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CAS No:
24554-26-5
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Formula:
C8H5N3O4S
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Chemical Name:
N-[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide
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Synonyms:
Formamide,N-[4-(5-nitro-2-furanyl)-2-thiazolyl]-;Formamide,N-[4-(5-nitro-2-furyl)-2-thiazolyl]-;N-[4-(5-Nitro-2-furanyl)-2-thiazolyl]formamide;N-[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide;FANFT;2-(Formylamino)-4-(5-nitro-2-furyl)thiazole;NSC 155010
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CAS No:
Description
N-(4-(5-nitro-2-furyl)thiazoyl)formamide appears as dark yellow powder or gold solid. (NTP, 1992)
N-(4-(5-nitro-2-furyl)thiazoyl)formamide appears as dark yellow powder or gold solid. (NTP, 1992)|A potent nitrofuran derivative tumor initiator. It causes bladder tumors in all animals studied and is mutagenic to many bacteria.
N-[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide Basic Attributes
239.20800
239.21
7N99PZG62O
155010
DTXSID4020953
2934100090
Characteristics
129.19000
3.11170
1.607g/cm3
549.5 to 562.1 °F (NTP, 1992)
441.1ºC at 760 mmHg
220.6ºC
1.675
less than 1 mg/mL at 70° F (NTP, 1992)
5.59E-08mmHg at 25°C
Insoluble in water.
Amides and Imides
A nitrated organosulfide and amide. Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Safety Information
Flash point data for this chemical are not available. It is probably combustible. (NTP, 1992)
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)
RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)
Drug Information
ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits very toxic fumes of sulfur oxides and nitrogen oxides. (NTP, 1992)
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)
FANFT
Computed Properties
Molecular Weight:239.21
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:239.00007682
Monoisotopic Mass:239.00007682
Topological Polar Surface Area:129
Heavy Atom Count:16
Complexity:285
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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