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Esorubicin hydrochloride

Esorubicin hydrochloride structure

CAS No:
63950-06-1
Formula:
C27H29NO10.ClH
Chemical Name:
Esorubicin hydrochloride
Synonyms:
5,12-Naphthacenedione,10-[[(2S,4R,6S)-4-aminotetrahydro-6-methyl-2H-pyran-2-yl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-,hydrochloride (1:1),(8S,10S)-;5,12-Naphthacenedione,10-[(4-aminotetrahydro-6-methyl-2H-pyran-2-yl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,hydrochloride,[2S-[2α(8R*,10R*),4β,6β]]-;5,12-Naphthacenedione,10-[[(2S,4R,6S)-4-aminotetrahydro-6-methyl-2H-pyran-2-yl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,hydrochloride,(8S,10S)-;4′-Deoxydoxorubicin hydrochloride;Esorubicin hydrochloride;Escorubicin hydrochloride;NSC 267469;IMI 58
Categories:
Biochemical Engineering > Saccharides

Description

Esorubicin Hydrochloride is a hydrochloride salt of esorubicin, a derivative of the anthracycline antineoplastic antibiotic doxorubicin, with potential antineoplastic activity. Esorubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent exhibits less cardiotoxicity than the parent antibiotic doxorubicin, but may cause more severe myelosupression compared to other compounds within the anthracycline class.

Esorubicin hydrochloride Basic Attributes

Molecular Weight：

563.98100

Exact Mass：

563.1558238 g/mol

EC Number：

264-575-1

UNII：

2UB1JJT82D

DSSTox ID：

DTXSID90213783

NCI Thesaurus Code：

C74943

Characteristics

PSA：

185.84000

XLogP3：

2.53280

Density：

1.55g/cm3

Boiling Point：

765.8ºC at 760 mmHg

Flash Point：

416.9ºC

Refractive Index：

1.693

Drug Information

MeSH：

Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms. (See all compounds classified as Antibiotics, Antineoplastic.)

MeSH Entry Terms：

4'-deoxyadriamycin

Computed Properties

Molecular Weight:564.0
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:5
Exact Mass:563.1558238
Monoisotopic Mass:563.1558238
Topological Polar Surface Area:186
Heavy Atom Count:39
Complexity:945
Defined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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Guide of Esorubicin hydrochloride

Description
Basic Attributes
Characteristics
Drug Information
Computed Properties
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