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Tripamide

Tripamide structure

CAS No:
73803-48-2
Formula:
C16H20ClN3O3S
Chemical Name:
Tripamide
Synonyms:
Benzamide,3-(aminosulfonyl)-4-chloro-N-[(3aR,4R,7S,7aS)-octahydro-4,7-methano-2H-isoindol-2-yl]-,rel-;Benzamide,3-(aminosulfonyl)-4-chloro-N-(octahydro-4,7-methano-2H-isoindol-2-yl)-,(3aα,4α,7α,7aα)-;4,7-Methano-2H-isoindole,benzamide deriv.;rel-3-(Aminosulfonyl)-4-chloro-N-[(3aR,4R,7S,7aS)-octahydro-4,7-methano-2H-isoindol-2-yl]benzamide;Tripamide;TDS (diuretic);TDS;E 614;Normonal;ADR 033;Toripamide;92308-33-3
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Tripamide Basic Attributes

Molecular Weight：

369.86600

Exact Mass：

369.87

DSSTox ID：

DTXSID2057817

Characteristics

PSA：

100.88000

XLogP3：

3.72000

Density：

1.51g/cm3

Refractive Index：

1.673

Drug Information

MeSH：

Agents that inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS which are concentrated in the thick ascending limb at the junction of the LOOP OF HENLE and KIDNEY TUBULES, DISTAL. They act as DIURETICS. Excess use is associated with HYPOKALEMIA and HYPERGLYCEMIA. (See all compounds classified as Sodium Potassium Chloride Symporter Inhibitors.)

MeSH Entry Terms：

E 614

Computed Properties

Molecular Weight:369.9
XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:369.0913904
Monoisotopic Mass:369.0913904
Topological Polar Surface Area:101
Heavy Atom Count:24
Complexity:605
Undefined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes