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Home > Encyclopedia > Cyclopenta[b]pyrrole-2(2H)-carboxylic acid, 1-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]hexahydro-

Cyclopenta[b]pyrrole-2(2H)-carboxylic acid, 1-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]hexahydro-

Cyclopenta[b]pyrrole-2(2H)-carboxylic acid, 1-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]hexahydro- structure

Cyclopenta[b]pyrrole-2(2H)-carboxylic acid, 1-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]hexahydro- 

structure
  • CAS No:

    83508-17-2

  • Formula:

    C23H32N2O5

  • Chemical Name:

    Cyclopenta[b]pyrrole-2(2H)-carboxylic acid, 1-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]hexahydro-

  • Synonyms:

    Cyclopenta[b]pyrrole-2(2H)-carboxylic acid, 1-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]hexahydro-

Description

A long-acting angiotensin-converting enzyme inhibitor. It is a prodrug that is transformed in the liver to its active metabolite ramiprilat.

Cyclopenta[b]pyrrole-2(2H)-carboxylic acid, 1-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]hexahydro- Basic Attributes

416.51

416.23112213 g/mol

Characteristics

95.9 Ų

1.200±0.06 g/cm3(Predicted)

616.2±55.0 °C(Predicted)

3.15±0.20(Predicted)

Drug Information

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility. (See all compounds classified as Angiotensin-Converting Enzyme Inhibitors.)

Acovil

Computed Properties

Molecular Weight:416.5
XLogP3:1.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:10
Exact Mass:416.23112213
Monoisotopic Mass:416.23112213
Topological Polar Surface Area:95.9
Heavy Atom Count:30
Complexity:619
Undefined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Guide of Cyclopenta[b]pyrrole-2(2H)-carboxylic acid, 1-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]hexahydro-

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