4-benzhydrylidene-1,1-dimethylpiperidin-1-ium
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4-benzhydrylidene-1,1-dimethylpiperidin-1-ium
structure -
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CAS No:
15394-62-4
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Formula:
C20H24N+
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Chemical Name:
4-benzhydrylidene-1,1-dimethylpiperidin-1-ium
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Synonyms:
Diphemanil;Diphemanil ion;Diphemanil cation;UNII-Q26TX1UD0W;Q26TX1UD0W;15394-62-4;MLS002154192;Diphemanil [WHO-DD];CAS-62-97-5;NCGC00016283-01;SMR001233482;SPBio_002218;Prestwick0_000079;Prestwick1_000079;Prestwick2_000079;Prestwick3_000079;4-(Diphenylmethylene)-1,1-dimethylpiperidinium;4-benzhydrylidene-1,1-dimethylpiperidin-1-ium;cid_6126;BSPBio_000297;Piperidinium, 4-(diphenylmethylene)-1,1-dimethyl-;BPBio1_000327;CHEMBL1201340;DTXSID7046968;BDBM74260;CHEBI:93636;ZINC1482039;DB13720;NCGC00016283-02;NCGC00016283-03;AB00513801;1,1-Dimethyl-4-benzhydrylidenepiperidine-1-ium;AB00513801_06;L000943;4-(diphenylmethylene)-1,1-dimethylpiperidin-1-ium;BRD-K93441486-067-03-7;Q27165329
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CAS No:
4-benzhydrylidene-1,1-dimethylpiperidin-1-ium Basic Attributes
278.4 g/mol
278.190874770 g/mol
Q26TX1UD0W
DTXSID7046968
A - Alimentary tract and metabolism
Drug Information
Used in the treatment of peptic ulcer, gastric hyperacidity, and hypermotility in gastritis and pylorospasm, and in the treatment of hyperhidrosis (excessive perspiration).
Diphemanil Methylsulfate is a quaternary ammonium anticholinergic. It binds muscarinic acetycholine receptors and thereby decreases secretory excretion of stomach acids as well as saliva and sweat.
Poorly absorbed from the gastrointestinal tract with an absolute bioavailability of 15 to 25%.
Diphemanil Methylsulfate exerts its action by primarily binding the muscarinic M3 receptor. M3 receptors are located in the smooth muscles of the blood vessels, as well as in the lungs. This means they cause vasodilation and bronchoconstriction. They are also in the smooth muscles of the gastrointestinal tract (GIT), which help in increasing intestinal motility and dilating sphincters. The M3 receptors are also located in many glands which help to stimulate secretion in salivary glands and other glands of the body.
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