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9-Hydroxy-2,5,11-trimethyl-6H-pyrido[4,3-b]carbazolium

9-Hydroxy-2,5,11-trimethyl-6H-pyrido[4,3-b]carbazolium structure

CAS No:
58337-34-1
Formula:
C18H17N2O
Chemical Name:
9-Hydroxy-2,5,11-trimethyl-6H-pyrido[4,3-b]carbazolium
Synonyms:
6H-Pyrido[4,3-b]carbazolium,9-hydroxy-2,5,11-trimethyl-;9-Hydroxy-2,5,11-trimethyl-6H-pyrido[4,3-b]carbazolium;9-Hydroxy-2-methylellipticine;2-Methyl-9-hydroxyellipticinium;N2-Methyl-9-hydroxyellipticinium;2-N-Methyl-9-hydroxyellipticinium;135941-09-2

Description

Elliptinium is a member of carbazoles.|Elliptinium is a derivative of the alkaloid ellipticine isolated from species of the plant family Apocynaceae, including Bleekeria vitensis, a plant with anti-cancer properties. As a topoisomerase II inhibitor and intercalating agent, elliptinium stabilizes the cleavable complex of topoisomerase II and induces DNA breakages, thereby inhibiting DNA replication and RNA and protein synthesis.

9-Hydroxy-2,5,11-trimethyl-6H-pyrido[4,3-b]carbazolium Basic Attributes

Molecular Weight：

277.3 g/mol

Exact Mass：

277.134088170 g/mol

UNII：

1F1959S062

NCI Thesaurus Code：

C90495

Characteristics

PSA：

39.9 Å²

Drug Information

MeSH：

Agents that are capable of inserting themselves between the successive bases in DNA, thus kinking, uncoiling or otherwise deforming it and therefore preventing its proper functioning. They are used in the study of DNA. (See all compounds classified as Intercalating Agents.)|Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

MeSH Entry Terms：

2-methyl-9-hydroxyellipticinium

Computed Properties

Molecular Weight:277.3
XLogP3:4.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Exact Mass:277.134088170
Monoisotopic Mass:277.134088170
Topological Polar Surface Area:39.9
Heavy Atom Count:21
Formal Charge:1
Complexity:401
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of 9-Hydroxy-2,5,11-trimethyl-6H-pyrido[4,3-b]carbazolium

Description
Basic Attributes
Characteristics
Drug Information
Computed Properties

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