Gepirone
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Gepirone
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CAS No:
83928-76-1
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Formula:
C19H29N5O2
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Chemical Name:
Gepirone
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Synonyms:
2,6-Piperidinedione,4,4-dimethyl-1-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-;4,4-Dimethyl-1-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,6-piperidinedione;Gepirone;104699-09-4
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CAS No:
Description
Gepirone is a N-arylpiperazine.|Gepirone has been used in trials studying the treatment of Cocaine-Related Disorders.
Drug Information
Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)|Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems. (See all compounds classified as Antidepressive Agents.)|Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS. (See all compounds classified as Serotonin Receptor Agonists.)
Gepirone has known human metabolites that include 1-[4-[4-(5-Hydroxypyrimidin-2-yl)piperazin-1-yl]butyl]-4,4-dimethylpiperidine-2,6-dione, 2-(1-piperazinyl)pyrimidine, 3-Hydroxy-1-[4-[4-(5-hydroxypyrimidin-2-yl)piperazin-1-yl]butyl]-4,4-dimethylpiperidine-2,6-dione, and 3-Hydroxygepirone.
4,4-dimethyl-1-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-2,6-piperidinedione
Computed Properties
Molecular Weight:359.5
XLogP3:1.8
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:359.23212518
Monoisotopic Mass:359.23212518
Topological Polar Surface Area:69.6
Heavy Atom Count:26
Complexity:476
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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