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Atamestane

Atamestane structure

CAS No:
96301-34-7
Formula:
C20H26O2
Chemical Name:
Atamestane
Synonyms:
Androsta-1,4-diene-3,17-dione,1-methyl-;1-Methylandrosta-1,4-diene-3,17-dione;SH 489;Metandroden;Atamestane

Description

Atamestane has been used in trials studying the treatment of Breast Cancer, Breast Neoplasms, and Neoplasms, Hormone-Dependent.|Atamestane is a synthetic steroidal substance with antineoplastic activity. Atamestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens. (NCI04)

Atamestane Basic Attributes

Molecular Weight：

298.4 g/mol

Exact Mass：

298.42

UNII：

62GA3K28B6

NCI Thesaurus Code：

C1224

Characteristics

PSA：

34.1 Å²

Melting Point：

165-167 °C @ Solvent: Diethyl ether, Hexane

Drug Information

MeSH：

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)

MeSH Entry Terms：

1-methyl-1,4-androstadiene-3,17-dione

Computed Properties

Molecular Weight:298.4
XLogP3:2.9
Hydrogen Bond Acceptor Count:2
Exact Mass:298.193280068
Monoisotopic Mass:298.193280068
Topological Polar Surface Area:34.1
Heavy Atom Count:22
Complexity:626
Defined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of Atamestane

Description
Basic Attributes
Characteristics
Drug Information
Computed Properties

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