Tiludronate disodium
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Tiludronate disodium
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CAS No:
149845-07-8
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Formula:
C7H9ClO6P2S.2Na
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Chemical Name:
Tiludronate disodium
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Synonyms:
Phosphonic acid,[[(4-chlorophenyl)thio]methylene]bis-,sodium salt (1:2);Phosphonic acid,[[(4-chlorophenyl)thio]methylene]bis-,disodium salt;SR 41319B;Tiludronate disodium;SR 41319G;Disodium tiludronate;Skelid
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CAS No:
Description
Tiludronate Disodium is the disodium salt form of tiludronate, a first-generation, non-nitrogenous bisphosphonate analogue of endogenous pyrophosphate. Tiludronate adsorbs to hydroxyapatite cells, and although the exact mechanism through which this bisphosphonate exerts its effect has yet to be fully elucidated, tiludronate appears to inhibit protein-tyrosine-phosphatase (PTP) in osteoclasts, thereby disrupting the cytoskeletal ring structure and suppressing the bone resorbing activity of osteoclasts. In addition, tiludronate appears to inhibit the vacuolar-type proton ATPase (V-ATPase) in osteoclasts. Altogether, this may reduce the number of osteoclasts, inhibit abnormal bone resorption and reduce bone turnover.
Tiludronate disodium Basic Attributes
362.57 g/mol
361.8922494 g/mol
BH6M93CIA0
DTXSID1048621
C61973
Drug Information
Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)
(4-chlorophenyl)thiomethylene bisphosphonic acid
Tiludronate disodium Use and Manufacturing
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
Computed Properties
Molecular Weight:362.57
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:361.8922494
Monoisotopic Mass:361.8922494
Topological Polar Surface Area:146
Heavy Atom Count:19
Complexity:320
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
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