Galocitabine
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Galocitabine
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CAS No:
124012-42-6
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Formula:
C19H22FN3O8
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Chemical Name:
Galocitabine
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Synonyms:
Cytidine,5′-deoxy-5-fluoro-N-(3,4,5-trimethoxybenzoyl)-;5′-Deoxy-5-fluoro-N-(3,4,5-trimethoxybenzoyl)cytidine;Ro 09-1390;Galocitabine;5′-Deoxy-5-fluoro-N4-(3,4,5-trimethoxybenzoyl)cytidine
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CAS No:
Description
Galocitabine is an orally available 5-fluorouracil (5-FU) prodrug with potential antineoplastic activity. Upon administration, galocitabine is converted into 5'-deoxy-5-fluorocytidine, 5'-deoxy-fluorouridine, and 5-FU. 5-FU is further metabolized into other cytotoxic metabolites that interfere with RNA and DNA synthesis via inhibition of thymidylate synthase. As a result, this agent eventually inhibits tumor cell growth.
Computed Properties
Molecular Weight:439.4
XLogP3:-0.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:6
Exact Mass:439.13909283
Monoisotopic Mass:439.13909283
Topological Polar Surface Area:139
Heavy Atom Count:31
Complexity:748
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
- Hot Searches
- acetate charge
- anthracene
- methyl formate
- pentanol
- h2cro4
- formaldehyde
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