Nicaraven
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Nicaraven
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CAS No:
79455-30-4
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Formula:
C15H16N4O2
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Chemical Name:
Nicaraven
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Synonyms:
3-Pyridinecarboxamide,N,N′-(1-methyl-1,2-ethanediyl)bis-;N,N′-(1-Methyl-1,2-ethanediyl)bis[3-pyridinecarboxamide];AVS;Nicaraven;1,2-Bis(nicotinamido)propane;Antevas;160888-15-3
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CAS No:
Drug Information
Investigated for use/treatment in cerebrovascular disease (unspecified).
Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. (See all compounds classified as Antioxidants.)
Nicaraven is presently being developed for the treatment of cerebral stroke including subarachnoid hemorrhage. This drug is promising because some data suggest it to have an ability to scavenge the hydroxyl radical under physiological conditions in vivo, while it also has a high permeability through the blood brain barrier.
1,2-bis(nicotinamido)propane
Computed Properties
Molecular Weight:284.31
XLogP3:0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:284.12732577
Monoisotopic Mass:284.12732577
Topological Polar Surface Area:84
Heavy Atom Count:21
Complexity:362
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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