N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide
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![N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220811/d0bd3efbc2ff4ad3a4b6353712ec323a.png "N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide")
N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide
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CAS No:
89459-25-6
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Formula:
C18H19N3O
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Chemical Name:
N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide
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Synonyms:
4-Acridinecarboxamide,N-[2-(dimethylamino)ethyl]-;N-[2-(Dimethylamino)ethyl]-4-acridinecarboxamide;NSC 601316;DACA;N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide
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CAS No:
Description
Acridine Carboxamide has been used in trials studying the treatment of Lung Cancer and Brain and Central Nervous System Tumors.|Acridine Carboxamide is a tricyclic acridine-based (or carboxamide-based) drug with dual topoisomerase inhibitor and potential antineoplastic activities. Acridine carboxamide inhibits both topoisomerases I and II and intercalates into DNA, resulting in DNA damage, the disruption of DNA repair and replication, the inhibition of RNA and protein synthesis, and cell death.
N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide Basic Attributes
293.4 g/mol
293.36
0N3V8R4E13
DTXSID60237739
C2203
Drug Information
Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)
DACA-N
Computed Properties
Molecular Weight:293.4
XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:293.152812238
Monoisotopic Mass:293.152812238
Topological Polar Surface Area:45.2
Heavy Atom Count:22
Complexity:385
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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