N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE
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![N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220811/5d51102ecd084042aae8f5a353d49b54.png "N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE")
N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE
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CAS No:
132172-61-3
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Formula:
C42H80ClNO4
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Chemical Name:
N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE
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Synonyms:
1,2-DIOLEOYL-3-TRIMETHYLAMMONIUM-PROPANE, CHLORIDE;DOTAP CHLORIDE SALT;N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE;N-[1-(2,3-DIOLEOYLOXY)PROPYL]-N,N,N-TRIMETHYL-AMMONIUM CHLORIDE SALT;N-[1-(2,3-DIOLEOYLOXY) PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE;TRIMETHYL[2,3-(DIOLEYLOXY)PROPYL]AMMONIUM CHLORIDE;2,3-Bis(oleoyloxy)-N,N,N-trimethyl-1-propanaminium;3-(Trimethylaminio)propane-1,2-diol 1,2-bis[(Z)-9-octadecenoate]
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CAS No:
Description
DOTAP chloride (1,2-Dioleoyl-3-trimethylammonium-propane chloride) is a potent cationic lipid widely used as a liposomal transfection reagent. DOTAP is also a strong activator of the innate immune system in animal cells and could serve as a potential candidate for the study of elicitors of plant immunity.
DOTAP, 1,2-Dioleoyl-3-trimethylammonium propane is a di-chain, or gemini, cationic surfactant. DOTAP has been used for in vitro and in vivo nucleic acid and protein delivery.
White Foam
N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE Basic Attributes
698.56
662.60873503 g/mol
White to Pale Yellow
Drug Information
Chemicals that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags. (See all compounds classified as Fluorescent Dyes.)
1,2-dioleoyl-3-trimethylammoniumpropane
N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE Use and Manufacturing
Small unilamellar liposomes containing DOTMA interact spontaneously with DNA to form lipid-DNA complexes with 100% entrapment of DNA. Facilitates fusion of the complex with the plasma membrane of tissue culture cells, resulting in both uptake and
1,2-dioleoyloxy-3-(trimethylammonium)propane (DOTAP) chloride has been used for the preparation of cationic liposome and liposome-DNA complex. It has also been used to assess tumor necrosis factor α (TNF- α) production.
Computed Properties
Molecular Weight:698.5
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:37
Exact Mass:697.5775877
Monoisotopic Mass:697.5775877
Topological Polar Surface Area:52.6
Heavy Atom Count:48
Complexity:754
Undefined Atom Stereocenter Count:1
Defined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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