Exatecan mesylateCAS:197720-53-9Purity:95%~99.99% heidi@coreychem.com Package:1KG;2.8USD
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Exatecan mesylateCAS:197720-53-9Purity:95%~99.99% heidi@coreychem.com Package:1KG;2.8USD
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CAS No:
197720-53-9
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Formula:
C24H22FN3O4.CH4O3S.2H2O
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Chemical Name:
Exatecan mesylateCAS:197720-53-9Purity:95%~99.99% heidi@coreychem.com Package:1KG;2.8USD
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Synonyms:
10H,13H-Benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-10,13-dione,1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-,(1S-trans)-,methanesulfonate (1:1) (salt),dihydrate;Exatecan mesylate hydrate
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CAS No:
Description
Exatecan mesilate hydrate is a pyranoindolizinoquinoline.|Exatecan Mesylate is a semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater potency than camptothecin and other camptothecin analogues. (NCI04)
Exatecan mesylateCAS:197720-53-9Purity:95%~99.99% heidi@coreychem.com Package:1KG;2.8USD Basic Attributes
567.6 g/mol
567.16867888 g/mol
D2VJ1CC26Q
C1679
Drug Information
Compounds that inhibit the activity of DNA TOPOISOMERASE I. (See all compounds classified as Topoisomerase I Inhibitors.)
(1S,9S)-1-amino-9-ethyl-5-fluoro-2,3-dihydro-9-hydroxy-4-methyl-1H,12H-benzo(de)pyrano(3',4'-6,7)indolizino(1,2-b)quinoline-10,13(9H,15H)dione methanesulfonate
Computed Properties
Molecular Weight:567.6
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:1
Exact Mass:567.16867888
Monoisotopic Mass:567.16867888
Topological Polar Surface Area:171
Heavy Atom Count:39
Complexity:1040
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:4
Compound Is Canonicalized:Yes
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