SNAP
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SNAP
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CAS No:
79032-48-7
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Formula:
C7H12N2O4S
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Chemical Name:
SNAP
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Synonyms:
S-Nitroso-acetyl penicillamine;2-acetamido-3-methyl-3-(nitrosothio)butyric acid;2-acetamido-3-methyl-3-nitrososulfanylbutanoic acid;2-acetamido-3-methyl-3-nitrososulfanyl-butanoic acid;N-Acetyl-S-nitroso-D-penicillaMine;N-ACETYL-3-(NITROSOTHIO)-D-VALINE;SNAP;SNAP(D)
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CAS No:
Description
A sulfur-containing alkyl thionitrite that is one of the NITRIC OXIDE DONORS.
Green Crystalline Solid
ChEBI: A nitroso compound that is N-acetyl-D-penicillamine in which the sulfanyl hydrogen is replaced by a nitroso group.
Nitric oxide donor that begins to evolve nitric oxide immediately upon solubilization in aqueous buffers (t1/2= 10 h). Mimics the actions of nitric oxide, including the relaxation of isolated bovine coronary artery rings (EC50= 130 nM). Markedly activates soluble guanylate cyclase. Also reported to cause the reversible inactivation of protein kinase C activity. Induces apoptosis in mouse thymocytes. Note: 1 set = 4 x 5 mg.
Drug Information
A diverse group of agents, with unique chemical structures and biochemical requirements, which generate NITRIC OXIDE. These compounds have been used in the treatment of cardiovascular diseases and the management of acute myocardial infarction, acute and chronic congestive heart failure, and surgical control of blood pressure. (Adv Pharmacol 1995;34:361-81) (See all compounds classified as Nitric Oxide Donors.)|Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)|Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)
N-Acetyl-S-Nitrosopenicillamine
Computed Properties
Molecular Weight:220.25
XLogP3:-0.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:220.05177804
Monoisotopic Mass:220.05177804
Topological Polar Surface Area:121
Heavy Atom Count:14
Complexity:254
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes