3-(1-benzylpiperidin-4-yl)-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)propan-1-one
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3-(1-benzylpiperidin-4-yl)-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)propan-1-one
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CAS No:
142852-50-4
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Formula:
C25H32N2O
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Chemical Name:
3-(1-benzylpiperidin-4-yl)-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)propan-1-one
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Synonyms:
Zanapezil;142852-50-4;UNII-0A0800O89N;CHEMBL75013;3-(1-benzylpiperidin-4-yl)-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)propan-1-one;0A0800O89N;Zanepezil;Zanapezil [INN];NCGC00183005-01;SCHEMBL678642;BDBM50037157;DB04859;91106-EP2305219A1;Q27095550;1-[(2,3,4,5-Tetrahydro-1H-1-benzazepin)-8-yl]-3-(1-benzylpiperidin-4-yl)propan-1-one;3-(1-Benzyl-piperidin-4-yl)-1-(2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-yl)-propan-1-one;3-(1-benzylpiperidin-4-yl)-1-(2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-yl)propan-1-one;8-[1-oxo-3-[1-(phenylmethyl)piperidine-4-yl]propyl]-2,3,4,5-tetrahydro-1H-1-benzazepine;1-Propanone, 3-(1-(phenylmethyl)-4-piperidinyl)-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)-;3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1h-1-benzazepin-8-yl)-1-propanone
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CAS No:
Description
Zanapezil (TAK-147) is a selective acetylcholine (ACh) esterase inhibitor under investigation as a drug for Alzheimer's disease (AD) treatment.
3-(1-benzylpiperidin-4-yl)-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)propan-1-one Basic Attributes
376.5 g/mol
376.251463648 g/mol
0A0800O89N
Drug Information
For the treatment of dementia in subjects with Alzheimer’s disease.
Zanapezil is an acetylcholinesterase inhibitor being developed by Takeda for the treatment of dementia in subjects with Alzheimer’s disease. In May 2003, the company discontinued development of the compound due to a lack of a dose-dependent effect in the trials.
Zanapezil inhibits the degradation of acetylcholine, a neurotransmitter, to prevent the reduction of cerebral acetylcholine levels and to enhance the mental function of patients with dementia. It is expected to act selectively on the central nervous system, resulting in fewer peripheral adverse reactions.
Computed Properties
Molecular Weight:376.5
XLogP3:4.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:376.251463648
Monoisotopic Mass:376.251463648
Topological Polar Surface Area:32.3
Heavy Atom Count:28
Complexity:479
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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