LEVORIN A2

Mixture of antifungal heptaene macrolides from Streptomyces griseus or Actinomyces levoris used topically in candidiasis. The antibiotic complex is composed of candicidins A, B, C, and D, of which D is the major component.

ChEBI: A 38-membered ring lactone containing seven (E)-double bonds between positions 22 and 35 and substituted by hydroxy groups at positions 9, 11, 13, 17 and 19, oxo groups at positions 3, 7 and 15, a carboxy group at position 18, a 3-amino-3, -dideoxymannopyranosyloxy group at position 21, a methyl group at position 36 and a 7-(4-aminophenyl)-5-hydroxy-4-methyl-7-oxoheptan-2-yl group at position 37. It is the major component of candicidin, a mixture of antifungal heptaene macrolides obtained fr m a strain of Streptomyces griseus.

Candicidin D (CndD) is an antibiotic, which exhibits antifungal activity through interaction with steroids in cell membranes. Candicidin D inhibits S. cerevisiae, Candida albicans and other Candida spp. with MIC of 0.25-1 μg/mL in RPMI-1640 medium.

Molecular Weight:1109.3
XLogP3:1.8
Hydrogen Bond Donor Count:11
Hydrogen Bond Acceptor Count:20
Rotatable Bond Count:10
Exact Mass:1108.57191383
Monoisotopic Mass:1108.57191383
Topological Polar Surface Area:364
Heavy Atom Count:79
Complexity:2130
Undefined Atom Stereocenter Count:17
Undefined Bond Stereocenter Count:7
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes