Sodium taurodeoxycholate hydrate
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Sodium taurodeoxycholate hydrate
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CAS No:
207737-97-1
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Formula:
C26H48NNaO7S
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Chemical Name:
Sodium taurodeoxycholate hydrate
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Synonyms:
2-[[(3alpha,5beta,12alpha)-3,12-Dihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid monosodium salt hydrate;TAURODEOXYCHOLIC ACID SODIUM SIGMAULTRA;2-([3α,12α-dihydroxy-24-oxo-5β-cholan-24-yl]amino)ethanesulfonic acid;Taurodeoxycholic acid hydrate sodium salt, 2-([3α,12α-Dihydroxy-24-oxo-5β-cholan-24-yl]amino)ethanesulfonic acid;N-(Deoxycholyl)taurine sodium salt, Taurodeoxycholic acid sodium salt, 3α,12α-Dihydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide sodium salt;Sodium taurodeoxycholate hydrate,2-([3α,12α-Dihydroxy-24-oxo-5β-cholan-24-yl]amino)ethanesulfonic acid, Taurodeoxycholic acid sodium salt hydrate;Ethanesulfonic acid,2-[[(3a,5b,12a)-3,12-dihydroxy-24-oxocholan-24-yl]aMino]-, sodiuM salt, hydrate (1:1:);Taurodeoxycholic Acid sodium salt hydrat
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CAS No:
Description
Sodium taurodeoxycholate hydrate is a bile salt-related, anionic detergent used for isolation of membrane proteins including inner mitochondrial membrane proteins. It has also been used in a study to investigate polymorphic behavior in protein surfactant mixtures.Sodium taurodeoxycholate hydrate has been used in a study to assess the effect of submicellar concentrations of bile salts on the lipid bilayer membrane. It has also been used in a study to investigate polymorphic behavior in protein-surfactant mixtures.
Sodium tauroursodeoxycholate is a bile salt which is naturally present in the small bowel.
The Na salt is dissolved in the smallest volume of H2O, a saturated solution of aqueous NaCl/Et2O is added and the mixture is stored at 0o for 24hours. Then shake the mixture well, keep it in the cold for another day and filter the crystals with gentle shaking, wash them with ice-cold saturated aqueous NaCl saturated with Et2O, dry them over CaCl2 and extract them with absolute EtOH. Add ~10mL of H2O to the solid followed by enough Et2O to incipient cloudiness. Store it overnight at 0o. Add ice-cold Et2O to make 250mL, collect the crystals, wash them with Et2O then pet ether and dry them in air. The purification can be repeated with NaCl and Et2O with ~85% recovery. NB: precipitation will not occur unless enough H2O is present. Its solubility in H2O is 10%. [Cortese J Am Chem Soc 59 2532 1937.] The free acid has m 141-144o. [Norman Ark Kemi 8 331 1956.] It forms mixed micelles and solubilises some membrane proteins [Hajjar et al. J Biol Chem 2 5 8 192 1983]. [Beilstein 10 IV 1611.]
Sodium taurodeoxycholate hydrate Basic Attributes
541.72
539.28926826
3901204
805-952-8
White to off-white
29242998
Characteristics
168 °C (dec.)(lit.)
H2O: 0.5M, clear, colorless to faintly yellow
221 Ų [M-H]-
Keep in dark place,Inert atmosphere,Room temperature
Safety Information
3
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Sodium taurodeoxycholate hydrate Use and Manufacturing
A hydrate form of sodium taurodeoxycholate (T009005), a steroid which rescues human colon cancer cells from apoptosis by activating EGFR-dependent PI3K/Akt signaling.
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