ethyl 10-(2-iodophenyl)undecanoate
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ethyl 10-(2-iodophenyl)undecanoate
structure -
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CAS No:
1320-11-2
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Formula:
C19H29IO2
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Chemical Name:
ethyl 10-(2-iodophenyl)undecanoate
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Synonyms:
Iophendylate,o; UNII-2990I809YH;
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CAS No:
Description
Liquid
Iophendylate is an organoiodine compound.|Iophendylate is a mixture of isomers used as contrast medium, mainly for brain and spinal cord visualization. Iophendylate is a myelographic oil-ester (U.S. Patent 2,348,231). Iophendylate, which was never shown to be safe, was initially introduced for use in small amounts (1-2cc) for locating spinal tumors. It next appeared on the world scene for high volume (12-15cc), routine use, in diagnosing disc herniations. A number of clinicians have published on the dangers of oil myelography. In 1942 Van Wagenen (a neurosurgical colleague of Warrens, at the University of Rochester) identified Iophendylate as causing chemical meningitis in 30 patients where "space-displacing masses within the spinal canal were suspected".
Characteristics
26.30000
6.07860
1.261g/cm3
423.3ºC at 760mmHg
209.8ºC
1.526
2.52e-05 g/L
2.16E-07mmHg at 25°C
Drug Information
Iophendylate is used as a contrast agent to locate spinal tumors.
Iophendylate is a myelographic oil-ester initially introduced for use in small amounts (1-2cc) for locating spinal tumors. Later, it was found to cause adhesive arachnoiditis. Because these substances are hyperbaric once they were placed in the subarachnoid space they would migrate to the distal portion, where they remained, producing progressive scarring.
Iophendylate has been shown to be both a radiographic and magnetic resonance (MR) contrast agent in patients with suspected cord abnormalities who underwent MR examination following myelography. The iophendylate appears as a linear band of high signal intensity along the dependent portion of the spinal canal on MR images obtained with a repetition time of 500 msec and an echo time of 30 msec.
Computed Properties
Molecular Weight:416.3
XLogP3:7
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:12
Exact Mass:416.12123
Monoisotopic Mass:416.12123
Topological Polar Surface Area:26.3
Heavy Atom Count:22
Complexity:293
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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