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Tacalcitol

Tacalcitol structure

CAS No:
57333-96-7
Formula:
C27H44O3
Chemical Name:
Tacalcitol
Synonyms:
1,3-Cyclohexanediol,4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,4R)-4-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-,(1R,3S,5Z)-;9,10-Secocholesta-5,7,10(19)-triene-1,3,24-triol,(1α,3β,5Z,7E,24R)-;(1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,4R)-4-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol;1α,24R-Dihydroxyvitamin D3;TV 02;Tacalcitol;1α,24(R)-Dihydroxycholecalciferol;PRI 2191;Bonalfa;Curatoderm;131801-95-1
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Tacalcitol Basic Attributes

Molecular Weight：

416.63600

Exact Mass：

416.64

Characteristics

PSA：

60.69000

XLogP3：

5.56060

Density：

1.06 g/cm3

Boiling Point：

565ºC at 760 mmHg

Flash Point：

238.4ºC

Refractive Index：

1.545

Storage Conditions：

Store at -20ºC

Safety Information

Packing level：

Hazard category：

6.1

Transport codes：

2025

hazard class code：

R50/53; R33; R26/27/28

safety instructions：

S61; S60; S45

RTECS Number：

OW2300000

Marks：

N; T+

Hazard Statements：

H300

Drug Function and Efficacy

Inhibitory effect on epidermal cell proliferation; Tacalcitol inhibits DNA synthesis and cell proliferation in rat epidermal culture cells and normal or psoriasis-derived human epidermal culture cells. Tacalcitol inhibits the activity of DOC (ornithine decarboxyl alcohol) in the epidermis of hairless rats that stimulate cell proliferation by applying TPA (12-O-tetradecanoylphospholipid). And by applying the ointment to psoriasis patients for 4 weeks, it can inhibit DNA synthesis and cell division, reduce S-phase cells, and inhibit epidermal cell proliferation. Differentiation-inducing effect on epidermal cells: For rat epidermal culture cells, Tacalcitol promotes the formation of intracellular insoluble membrane (cornified envelope) and increases transglutaminase (Tgase) activity. For the epidermis of hairless rats, Tgase activity is increased. For normal human cultured epidermal cells, Tacalcitol promotes the synthesis of invogulin, a precursor protein shell of intracellular insoluble membrane. In addition, the skin of the lesion site of psoriasis patients after application was observed under an electron microscope, and normal keratinization tendency such as the formation of a protein pattern (keratin pattern) of the stratum corneum and the formation of a granular layer with epidermal transparent keratin (keratohyalin) was found. It has affinity for the specific protein receptor of 1α, 25-(OH)2D3 of epidermal cells.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Tacalcitol ointment
Ingredients	Each 1g of Monerfu ointment contains 2 micrograms of tacalcitol.
Indication	Effects on epidermal cultured cells and human epidermal cultured cells obtained from normal persons or psoriasis patients: Tacalcitol has DNA synthesis and cell proliferation inhibition effects. Effects on the epidermis of hairless mice in which cell proliferation was induced by TPA application: The activity of ODC (ornithine decarboxylase), a cell proliferation index, was inhibited. The ointment was applied to psoriasis patients for 4 weeks and it was found that it had an inhibitory effect on DNA synthesis and cell division. It reduced the effect on S phase cells and had an inhibitory effect on epidermal cell proliferation. Effect on epidermal cell differentiation induction: In rat epidermal cultured cells, it was found that Tacalcitol could promote the formation of insoluble membranes in cells and increase the activity of transglutaminase. It increased the activity of Tgase in the epidermis of hairless mice. In normal human epidermal cultured cells, Tacalcitol promoted the synthesis of precursor proteins of insoluble membranes in cells.
Specifications	2 μg/g

Mendelfutacalcitol ointment

Tacalcitol ointment
Ingredients	The chemical name of tacalcitol is ()-(5Z, 7E, 24R)-9,10-secocholesta-5,7,10(19)-triene-1α,3β,24-triolmonohydrate. Each 1g contains 2.087ug of tacalcitol (anhydrous substance 2ug: 0.0002%).
Specifications	10g*1pc/box

Registered Holders

LUKASIEWICZ Research Network-INDUSTRIAL CHEMISTRY INSTITUTE

Japan
Active
Nanjing Heron Pharmaceutical Co., Ltd.

China
Active

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