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Muramyl Dipeptide

Muramyl Dipeptide structure

CAS No:
53678-77-6
Formula:
C19H32N4O11
Chemical Name:
Muramyl Dipeptide
Synonyms:
acetylmuramyl-alanyl-isoglutamine;n(sup2)-(n-(n-acetylmuramoyl)-l-alanyl)-d-alpha-glutamin;n(sup2)-(n-(n-acetylmuramoyl)-l-alanyl)-d-alpha-glutamine;Ac-muramyl-Ala-D-Glu-NH;N-AC-MURAMYL-ALA-D-GLU-NH2;N-AC-MURAMYL-ALA-D-GLU-NH2 2H2O;N-ACETYL-MURAMYL-L-ALA-D-ISOGLN;N-ACETYLMURAMYL-L-ALA-D-ISOGLUTAMINE
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Muramyl dipeptide is a glycopeptide that is N-propionyl-L-alanyl-D-alpha-glutamine in which the pro-R hydrogen of the propionyl group has been replaced by the oxygen at position 3 of 2-acetamido-2-deoxy-beta-D-glucopyranose. A peptidoglycan constituent of both Gram-positive and Gram-negative bacteria. It has a role as an immunological adjuvant.|Peptidoglycan immunoadjuvant originally isolated from bacterial cell wall fragments; also acts as pyrogen and may cause arthritis; stimulates both humoral and cellular immunity.

Muramyl Dipeptide Basic Attributes

Molecular Weight：

492.48

Exact Mass：

492.48

BRN：

4220745

EC Number：

258-696-9

Color/Form：

White to off-white

Characteristics

Density：

1.390±0.06 g/cm3(Predicted)

Boiling Point：

1071.8±65.0 °C(Predicted)

PKA：

4.44±0.10(Predicted)

Critical Temperature & Pressure：

-20°C

Safety Information

wgk germany：

safety instructions：

22-24/25

RTECS Number：

MA2275260

Drug Information

MeSH：

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)

MeSH Entry Terms：

Acetylmuramyl Alanyl Isoglutamine

Muramyl Dipeptide Use and Manufacturing

Immunological adjuvant.

N-Acetylmuramyl-L-alanyl-D-isoglutamine hydrate has been used in staphylococcal cell wall preparation to induce the release of TNF from human monocytes.

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Muramyl dipeptide(MDP)

CAS No.: 53678-77-6

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Guide of Muramyl Dipeptide

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
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