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POPC

POPC structure

CAS No:
26853-31-6
Formula:
C42H82NO8P
Chemical Name:
POPC
Synonyms:
3-SN-PHOSPHATIDYLCHOLINE, 2-OLEOYL-1-PALMITOYL;L-ALPHA-PHOSPHATIDYLCHOLINE, BETA-OLEOYL-GAMMA-PALMITOYL;L-BETA-OLEOYL-GAMMA-PALMITOYL-ALPHA-LECITHIN;3,5,8-Trioxa-4-phosphahexacos-17-en-1-aMiniuM,4-hydroxy-N,N,N-triMethyl-9-oxo-7-[[(1-oxohexadecyl)oxy]Methyl]-, inner salt,4-oxide, (7R,17Z)-;(7R,17Z)-4-Hydroxy-N,N,N-trimethyl-9-oxo-7-[[(1-oxohexadecyl)oxy]methyl]-3,5,8-trioxa-4-phosphahexacos-17-en-1-aminium 4-oxide, inner salt;1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine;3-sn-Phospha;1-PALMITOYL-2-OLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE;16:0-18:1 PC
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC) is a phospholipid containing 16:0 and 18:1 fatty acids at thesn-1 andsn-2 positions, respectively. It belongs to a class of phospholipids that are a major component of biological membranes. This compound can be used for liposome production in order to study the properties of lipid bilayers.

1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPhtCho), is a phosphatidylcholine, that belongs to a class of phospholipids that are a major component of biological membranes. This compound has been shown to decrease the expression of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor subunit GluR1 on the plasma membrane of CA1 region of rat hippocampal slices.

ChEBI: 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine is a phosphatidylcholine 34:1 in which the 1- and 2-acyl groups are specified as hexadecanoyl (palmitoyl) and 9Z-octadecenoyl (oleoyl) respectively. It has a role as a mouse metabolite. It is a phosphatidylcholine 34:1 and a 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine betaine. It is functionally related to a hexadecanoic acid and an oleic acid.

POPC is typically considered one of the model lipids for biophysical experiments. The fatty acid composition, i.e., saturated chain in the sn-1 position and unsaturated chain in the sn-2 position, mimics mammalian phospholipid composition. Since the major constituent in Egg PC is 1-palmitoyl-2-oleoyl PC, POPC is an excellent synthetic substitute for EPC.

POPC Basic Attributes

Molecular Weight：

760.08

BRN：

4173237

EC Number：

248-056-7

Color/Form：

White to off-white

Characteristics

Melting Point：

-3 °C

Critical Temperature & Pressure：

-20°C

Safety Information

wgk germany：

safety instructions：

22-24/25

POPC Use and Manufacturing

The effect of non-ionic detergent on liposomes was studied with giant POPC liposomes. Increasing concentrations of detergent cause tubular protrusions, then indentations, to develop on spherical liposomes. At higher detergent concentrations, the liposomes burst.

Glycerophospholipids act as regulators of various enzyme activities, and can be used as biological markers to indicate pathological states.

16:0-18:1 PC has been used in the preparation of liposomes for the muramyl tripeptide encapsulation. It has also been used in the preparation of membrane scaffold protein 1 nanodisc. 16:0-18:1 PC may be used in the synthesis of discoidal reconstituted high-density lipoproteins.

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