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PAGOCLONE

PAGOCLONE structure

CAS No:
133737-32-3
Formula:
C23H22ClN3O2
Chemical Name:
PAGOCLONE
Synonyms:
2-(7-Chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-1-isoindolinone;Ip 456;Rp 62955;2-(7-Chloro-1,8-naphthyridin-2-yl)-3-(5-Methyl-2-oxohexyl)isoindolin-1-one;(+)-RP-59037; IP-456; RP-62955; CI-1043;CI-1043;AGOCLONE;inhibit,GABA Receptor,γ-Aminobutyric acid Receptor,Gamma-aminobutyric acid Receptor,IP 456,RP 62955,RP62955,Pagoclone,Inhibitor
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Pagoclone is an anxiolytic drug from the cyclopyrrolone family, which is related to other more well known drugs such as the sleeping medication zopiclone. It is one of a relatively recently developed class of medicines known as the nonbenzodiazepines, which have similar effects to the older benzodiazepine group, but with quite different chemical structures.

Pagoclone is a drug that belongs to the class of cyclopyrrolones. It binds to the benzodiazepine binding site on GABAA receptors and acts as a negative allosteric modulator, thereby enhancing the inhibitory effects of GABA and reducing neuronal excitability.

PAGOCLONE Basic Attributes

Molecular Weight：

407.89

Exact Mass：

407.89

EC Number：

225-799-5

UNII：

38VAG2SA33

Color/Form：

White to off-white

Characteristics

Density：

1.273±0.06 g/cm3(Predicted)

Boiling Point：

582.1±50.0 °C(Predicted)

PKA：

1.62±0.30(Predicted)

Drug Information

Drug Indication：

For the potential treatment of panic and anxiety disorders.

Pharmacology：

Pagoclone was originally developed as an anti-anxiety drug, but never commercialised. It is a partial agonist acting at GABAA receptors in the brain. In contrast to zopiclone, pagoclone produces anxiolytic effects with little or no sedative or amnestic actions at low doses.

Mechanism of Action：

Pagoclone is a subtype-selective drug which binds primarily to the alpha2/alpha3 subtypes of the GABAA receptor which are responsible for the anti-anxiety effects of these kind of drugs, but has relatively little efficacy at the alpha1 subtype which produces the sedative and memory loss effects.

MeSH Entry Terms：

2-(7-chloro-1.8-naphthyridin-2-yl)-2,3-dihydro-3-(5-methyl-2-oxohexyl)-1H-isoindol-1-one

PAGOCLONE Use and Manufacturing

Anti-anxiety agent.

Recommended Suppliers of PAGOCLONE

Shaanxi Dideu Medichem Co. Ltd Contact Supplier

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Pagoclone 1

CAS No.: 133737-32-3

Grade: Pharmaceutical Grade

Content: 99%

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