Ozanimod
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Ozanimod
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CAS No:
1306760-87-1
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Formula:
C23H24N4O3
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Chemical Name:
Ozanimod
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Synonyms:
Benzonitrile, 5-[3-[(1S)-2,3-dihydro-1-[(2-hydroxyethyl)aMino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-Methylethoxy)- (free base);Ozanimod (RPC1063);Ozanimod;Benzonitrile, 5-[3-[(1S)-2,3-dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)-;5-[3-[(1S)-2,3-Dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile;(S)-5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile;oxanimod(RPC1063);RPC1063 Ozanimod
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CAS No:
Description
Ozanimod is a sphingosine-1-phosphate receptor 1 (S1P1) and S1P5agonist. It induces GTPγS binding in cell membranes expressing human S1P1or S1P5(EC50s = 0.41 and 11 nM, respectively) but not cell membranes expressing S1P2or S1P3receptors (EC50s = >10,000 nM for both). Ozanimod (0.2 mg/kg) reduces the number of peripheral lymphocytes in rats. It reduces disease severity and the number of circulating lymphocytes in a mouse model of experimental autoimmune encephalomyelitis (EAE). Ozanimod (0.3 and 1 mg/kg) reduces disease severity and body weight loss in a mouse model of TNBS-induced colitis. Formulations containing ozanimod have been used in the treatment of relapsing multiple sclerosis and ulcerative colitis.
Characteristics
1.30±0.1 g/cm3(Predicted)
134-137°C
648.3±65.0 °C(Predicted)
14.73±0.10(Predicted)
-20°C Freezer
Ozanimod Use and Manufacturing
Ozanimod is an agonist that binds to S1P1 and S1P5 receptors. Experiments on rodents revealed that Ozanimod is effective against autoimmune diseases.
Ozanimod is an agonist that binds to S1P1 and S1P5 receptors. Experiments on rodents revealed that Ozanimod is effective against autoimmune diseases.
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