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Ozanimod

Ozanimod structure

CAS No:
1306760-87-1
Formula:
C23H24N4O3
Chemical Name:
Ozanimod
Synonyms:
Benzonitrile, 5-[3-[(1S)-2,3-dihydro-1-[(2-hydroxyethyl)aMino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-Methylethoxy)- (free base);Ozanimod (RPC1063);Ozanimod;Benzonitrile, 5-[3-[(1S)-2,3-dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)-;5-[3-[(1S)-2,3-Dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile;(S)-5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile;oxanimod(RPC1063);RPC1063 Ozanimod
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Ozanimod is a sphingosine-1-phosphate receptor 1 (S1P1) and S1P5agonist. It induces GTPγS binding in cell membranes expressing human S1P1or S1P5(EC50s = 0.41 and 11 nM, respectively) but not cell membranes expressing S1P2or S1P3receptors (EC50s = >10,000 nM for both). Ozanimod (0.2 mg/kg) reduces the number of peripheral lymphocytes in rats. It reduces disease severity and the number of circulating lymphocytes in a mouse model of experimental autoimmune encephalomyelitis (EAE). Ozanimod (0.3 and 1 mg/kg) reduces disease severity and body weight loss in a mouse model of TNBS-induced colitis. Formulations containing ozanimod have been used in the treatment of relapsing multiple sclerosis and ulcerative colitis.

Ozanimod Basic Attributes

Molecular Weight：

404.46

Exact Mass：

404.46

EC Number：

814-246-9

Color/Form：

White to Off-White

Characteristics

Density：

1.30±0.1 g/cm3(Predicted)

Melting Point：

134-137°C

Boiling Point：

648.3±65.0 °C(Predicted)

PKA：

14.73±0.10(Predicted)

Critical Temperature & Pressure：

-20°C Freezer

Safety Information

Storage features：

Store at -20°C

Ozanimod Use and Manufacturing

Ozanimod is an agonist that binds to S1P1 and S1P5 receptors. Experiments on rodents revealed that Ozanimod is effective against autoimmune diseases.

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