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Home > Encyclopedia > Ethyl (hydroxyimino)cyanoacetate potassium salt

Ethyl (hydroxyimino)cyanoacetate potassium salt

Ethyl (hydroxyimino)cyanoacetate potassium salt structure

Ethyl (hydroxyimino)cyanoacetate potassium salt 

structure
  • CAS No:

    158014-03-0

  • Formula:

    C5H5KN2O3

  • Chemical Name:

    Ethyl (hydroxyimino)cyanoacetate potassium salt

  • Synonyms:

    2-Cyano-2-(hydroxyimino)acetic acid ethyl ester, potassium salt;Ethyl (hydroxyimino)cyanoacetate potassium salt;K-Oxyma;Cyano(hydroxyimino)acetic acid ethyl ester potassium salt;2-Cyano-2-(hydroxyimino)acetic acid ethyl ester potassium salt (1:1);Ethyl (hydroxyimino)cyanoacetate potassium;K-Oxyma≥ 99% (HPLC);K-Oxyma Pure Novabiochem

  • Categories:

    Pharmaceutical Intermediates  >  Bulk Drug Intermediates

Description

Bright yellow powder

Ethyl (hydroxyimino)cyanoacetate potassium salt Basic Attributes

180.2031

179.99372351

Dark Yellow

2928 00 90

Characteristics

145-155°C

2-8°C

Safety Information

3

T

36/37-45

20/21-25-43

UN 3439 6.1 / PGIII

Ethyl (hydroxyimino)cyanoacetate potassium salt Use and Manufacturing

Useful in peptide coupling on mild acid-labile resins with minimal to no cleavage of the peptide from the resin due to its more alkaline character. This can be used to replace the explosive HOBt and HOAt.


Non-explosive replacement for HOBt and HOAt with at least comparable performance to HOAtOutperforms HOAt in sterically demanding peptide bond formationsCompatible with carbodiimide-mediated; solution and solid phase peptide coupling;Less epimerization than HOBt in fragment condensation reactionsK-salt especially useful in peptide coupling on mild acid-labile resins such as 2-chlorotrityl; leading to minimal to no cleavage of the peptide from the resin due to its more alkaline characterK-salt has a higher melting point than OxymaPure


Ethyl (hydroxyimino)cyanoacetate potassium salt is a Non-explosive replacement for HOBt and HOAt with at least comparable performance to HOAt Outperforms HOAt in sterically demanding peptide bond formations Compatible with carbodiimide-mediated; solution and solid phase peptide coupling; Less epimerization than HOBt in fragment condensation reactions K-salt especially useful in peptide coupling on mild acid-labile resins such as 2-chlorotrityl; leading to minimal to no cleavage of the peptide from the resin due to its more alkaline character K-salt has a higher melting point than OxymaPure.

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