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Lidocaine hydrochloride

Lidocaine hydrochloride structure

CAS No:
6108-05-0
Formula:
C14H25ClN2O2
Chemical Name:
Lidocaine hydrochloride
Synonyms:
N1-(2,6-dimethylphenyl)-N2,N2-diethylglycinamide hydrochloride hydrate;Linocaine hydrochloride(lidocaine HCL);LIDOCAINE HCL BP (INJECTABLE GRADE);Lignocaine monohydrate hydrochloride, Xylocaine monohydrate hydrochloride, 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide monohydrate hydrochloride;2-Dimethylamino-N-(2,6-dimethylphenyl)acetamide hydrochloride;Lidocaine Hydrochloride BP98 USP24;Xylocaine hydrochloride monohydrate;Lidocaine Hydrochloride hydrate
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Linocaine hydrochloride is a white or almost white, crystalline powder with slightly bitter and numbing taste. Soluble in water, ethanol and organic solvents, insoluble in ether. The aqueous solution does not decompose under acid and alkali conditions, and it rarely deteriorates after repeated autoclaving.

ChEBI: Linocaine hydrochloride is the monohydrate form of lidocaine hydrochloride. It is a local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of Procaine but its duration of action is shorter than that of bupivacaine or prilocaine.

Lidocaine hydrochloride Basic Attributes

Molecular Weight：

288.82

EC Number：

612-079-4

TSCA：

Yes

Color/Form：

white

HScode：

2924296000

Characteristics

Melting Point：

75-79℃

Water Solubility：

Soluble in water (50 mg/ml), chloroform, ethanol, and benzene. Insoluble in diethyl ether.

Critical Temperature & Pressure：

2-8°C

Safety Information

Hazard category：

6.1

wgk germany：

hazard class code：

safety instructions：

RTECS Number：

AN7700000

Hazard Statements：

RIDADR：

UN 2811 6.1/PG 3

Exposure Prevention：

Linocaine hydrochloride is an anesthetic of the amide group, like articaine or bupivacaine. Immediate-type IgE-dependent reactions are rare, and delayed-type contact dermatitis is exceptional. Cross-reactivity between the different amide anesthetics is not systematic.

Lidocaine hydrochloride Use and Manufacturing

Linocaine hydrochloride is a fast voltage-gated sodium channel blocker that used in Local anesthesia and heart rhythm disorders. Its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine.

Drug Function and Efficacy

This product is an amide local anesthetic. After blood absorption or intravenous administration, it has obvious biphasic effects of excitation and inhibition on the central nervous system, and there may be no precursor excitation. When the blood concentration is low, analgesia and drowsiness occur, and the pain threshold increases; with increasing doses, the effect or toxicity increases, and it has an anticonvulsant effect at sub-toxic blood concentrations; convulsions may occur when the blood concentration exceeds 5μg·ml-1. At low doses, this product can promote the outflow of K in myocardial cells, reduce myocardial autonomy, and have an anti-ventricular arrhythmia effect; at therapeutic doses, it has no obvious effect on the electrical activity of myocardial cells, atrioventricular conduction, and myocardial contraction; further increases in blood concentrations can cause a slowing of heart conduction velocity, atrioventricular conduction block, inhibition of myocardial contractility, and a decrease in cardiac output.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Lidocaine Hydrochloride Injection (Solvent)
Ingredients	The main ingredient of this product is lidocaine hydrochloride. Its chemical name is N-(dichloroxylyl)-2-(diethylamino)acetamide hydrochloride monohydrate.
Indication	1 When used in combination with cimetidine and beta-blockers such as propranolol, metoprolol, and nadolol, lidocaine metabolism in the liver is inhibited, lidocaine blood concentration increases, and adverse reactions of the heart and nervous system may occur. The lidocaine dose should be adjusted, and electrocardiogram monitoring and lidocaine blood concentration should be performed. 2 Barbiturates can promote lidocaine metabolism, and the combination of the two drugs can cause bradycardia and sinus arrest. 3 When used in combination with procainamide, transient delirium and hallucinations may occur, but it does not affect the blood concentration of this product. 4 Isoproterenol increases the total clearance of this product due to increased hepatic blood flow; norepinephrine reduces the total clearance of this product due to reduced hepatic blood flow.
Specifications	2ml:4mg
Manufacturer	Hubei Xinghua Pharmaceutical Co., Ltd.

Lidocaine Hydrochloride Injection
Ingredients	The main ingredient of this product is lidocaine hydrochloride. Its chemical name is N-(dichloroxylyl)-2-(diethylamino)acetamide hydrochloride monohydrate.
Indication	1 When used in combination with cimetidine and beta-blockers such as propranolol, metoprolol, and nadolol, lidocaine metabolism in the liver is inhibited, lidocaine blood concentration increases, and adverse reactions of the heart and nervous system may occur. The lidocaine dose should be adjusted, and electrocardiogram monitoring and lidocaine blood concentration should be performed. 2 Barbiturates can promote lidocaine metabolism, and the combination of the two drugs can cause bradycardia and sinus arrest. 3 When used in combination with procainamide, transient delirium and hallucinations may occur, but it does not affect the blood concentration of this product. 4 Isoproterenol increases the total clearance of this product due to increased hepatic blood flow; norepinephrine reduces the total clearance of this product due to reduced hepatic blood flow.
Specifications	20ml:0.4g
Manufacturer	Southwest Pharmaceutical Co., Ltd.

Lidocaine Hydrochloride Injection (Solvent)
Ingredients	The main ingredient of this product is lidocaine hydrochloride. Its chemical name is N-(dichloroxylyl)-2-(diethylamino)acetamide hydrochloride monohydrate.
Indication	1 When used in combination with cimetidine and beta-blockers such as propranolol, metoprolol, and nadolol, lidocaine metabolism in the liver is inhibited, lidocaine blood concentration increases, and adverse reactions of the heart and nervous system may occur. The lidocaine dose should be adjusted, and electrocardiogram monitoring and lidocaine blood concentration should be performed. 2 Barbiturates can promote lidocaine metabolism, and the combination of the two drugs can cause bradycardia and sinus arrest. 3 When used in combination with procainamide, transient delirium and hallucinations may occur, but it does not affect the blood concentration of this product. 4 Isoproterenol increases the total clearance of this product due to increased hepatic blood flow; norepinephrine reduces the total clearance of this product due to reduced hepatic blood flow.
Specifications	5ml:10mg
Manufacturer	Yantai Luyin Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

CAMBREX KARLSKOGA AB

France
Active
Guangdong POSH Healthcare Pharmaceutical Co., Ltd.

China
Active
Shanxi Shuangyan Pharmaceutical Co., Ltd.

China
Active

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