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LUCIFERASE

LUCIFERASE structure

CAS No:
61970-00-1
Chemical Name:
LUCIFERASE
Synonyms:
ALKANAL-REDUCED FMN-OXYGEN OXIDOREDUCTASE;Luciferase Photinus pyralis (firefly);Luciferase, Firefly, Recomb.;Luciferase (firefly luciferin);LUCIFERASE, RECOMBINANT, FROM LUCIOLA MINGRELICA;LUCIFERASE FROM FIREFLY, WHITE POWDER, SOLUBLE*;LUCIFERASE, FROM FIREFLY WITH*TRIS-ASPAR TIC ACID;LUCIFERASE FROM FIREFLY SOLUBLE*WITH TRI S-SUCCINIC
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Luciferase (firefly recombinant) is a light-generating enzyme that catalyzes an oxidative reaction, using luciferin, ATP, and molecular oxygen to produce oxyluciferin, which yields visible light. The bioluminescence of this ATP-dependent luciferase is commonly used in reporter systems that are amenable to high-throughput screening.

Firefly luciferase catalyzes the reaction of luciferin with ATP and leads to the production of yellow-green light. The enzyme has a molecular weight of 62kDa and is expressed in peroxisomes. Luciferase is considered as a model to study protein–anesthetic interactions. Firefly luciferase is highly useful in cell biology and molecular biology, as a reporter of gene function and for the quantification of ATP.

Luciferase produced in E.Coli is a single, non-glycosylated polypeptide chain containing 571 amino acids (1-550 a.a.) and having a molecular mass of 62.9kDa.Luciferase is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Escherichia Coli

LUCIFERASE Basic Attributes

Molecular Weight：

EC Number：

263-359-4

Color/Form：

white

Characteristics

Critical Temperature & Pressure：

-20°C

Safety Information

wgk germany：

hazard class code：

Xi,Xn,T

safety instructions：

26-36/37-24/25-23-22-61-45-53

Hazard Statements：

36/37/38-22-52/53-45

LUCIFERASE Use and Manufacturing

Firefly luciferase is used extensively in molecular and cell biology, in particular for the efficient detection and quantitation of ATP and as a reporter for genetic function.

Luciferase fromPhotinus pyralis(firefly) has been used as a component of lysis solution to measure luminescence signals, as part of the study to determine chemical signals which can activate the karrikin insensitive 2 (KAI2) pathway.

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