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Capmatinib hydrochloride

Capmatinib hydrochloride structure

CAS No:
1865733-40-9
Formula:
C23H20ClFN6O2
Chemical Name:
Capmatinib hydrochloride
Synonyms:
Capmatinib hydrochloride;Capmatinib HCl hydrate (INCB-28060;Capmatinib 2HCl.H2O;INC-280 2HCl.H2O;INCB28060 2HCl.H2O;NVP-INC280 2HCl.H2O;Capmatinib Hydrochloride Hydrate （INCB28060）;S114,SNU-5,ATP competitive,Balb/c nu/nu mice,U-87MG,INCB-28060 dihydrochloride,orally active,Capmatinib dihydrochloride,Capmatinib 2HCl.H-2O,Capmatinib 2HCl.H2O,INC280 dihydrochloride,Apoptosis,inhibit,Inhibitor,c-Met/HGFR,H441
Categories:
Active Pharmaceutical Ingredients > Antineoplastic Agents

Description

Capmatinib Hydrochloride is the hydrochloride salt form of capmatinib, an orally bioavailable inhibitor of the proto-oncogene c-Met (also known as hepatocyte growth factor receptor (HGFR)) with potential antineoplastic activity. Capmatinib selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis.

Capmatinib dihydrochloride hydrate is a orally active,reversible MET tyrosine kinase inhibitor that received approval for advanced non-small cell lung cancer(NSCLC) harboring MET exon 14 skipping mutationa. Capmatinib dihydrochloride hydrate can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib dihydrochloride hydrate potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib dihydrochloride hydrate is largely metabolized by CYP3A4 and aldehyde oxidase[1-3].

Capmatinib hydrochloride Basic Attributes

Molecular Weight：

466.9

Exact Mass：

502.1087075

UNII：

C2A374O70X

NCI Thesaurus Code：

C138995

Color/Form：

White to light yellow

Characteristics

Toxicity：

Effects During Pregnancy and Lactation No information is available on the clinical use of capmatinib during breastfeeding. Because capmatinib is 96% bound to plasma proteins, the amount in milk is likely to be low. The manufacturer recommends that breastfeeding be discontinued during capmatinib therapy and for 1 week after the last dose.

Drug Information

MeSH Entry Terms：

2-fluoro-4-(7-((quinolin-6-yl)methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzoic acid

Capmatinib hydrochloride Use and Manufacturing

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Recommended Suppliers of Capmatinib hydrochloride

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Capmatinib hydrochloride 1-(1-amminoeethyl)cycloproupanol CAS 1865733-40-9 99% Hot 99% Hot Sale Pharmaceutical Best Service Pharmaceutical Producer

Unit Price: $5 /MT FOB

CAS No.: 1865733-40-9

Grade: Pharmaceutical Grade

Content: 99.63%

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