4-AMIDINOPYRIDINEHYDROCHLORIDEPYRIDINE-4-CARBOXIMIDAMIDEHYDROCHLORIDE

White powder

4-Cyanopyridine (20.0 g, 0.2 mol) was dissolved in dry MeOH (200 mL) andpowdered sodium methoxide (1.1 g, 20 mmol) was added in one portion. Thesolution was stirred overnight at room temperature. After addition of NH4Cl (16.5 g, 0.31 mol), the reaction mixture was heated at reflux for 4 h and then cooled toambient temperature. The solvent was evaporated and absolute EtOH (300 mL) was added.Then the mixture was heated to reflux. After 15 min, the solids were filtered off and thefiltrate was allowed to cool to room temperature and stand overnight. Additional inorganicsalts were filtered off, and the reaction mixture was concentrated to approximately volumeand filtered to afford 24.0 g (76percent) of the title compoundNaOMe (5.4 g, 100 mmol) was added to a stirred solution of 4-pyridinecarbonitrile (10.0 g, 96.1 mmol) in dry MeOH (50 mL) and the mixture stirred at reflux temperature for 2 h. NH(d)

Molecular Weight:157.60
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:157.0406750
Monoisotopic Mass:157.0406750
Topological Polar Surface Area:62.8
Heavy Atom Count:10
Complexity:105
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes