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Methyl methoxyacetate

Methyl methoxyacetate structure

CAS No:
6290-49-9
Formula:
C4H8O3
Chemical Name:
Methyl methoxyacetate
Synonyms:
Acetic acid,2-methoxy-,methyl ester;Acetic acid,methoxy-,methyl ester;Methyl methoxyacetate;Methyl 2-methoxyacetate;Methyl α-methoxyacetate;Methoxyacetic acid methyl ester;NSC 61447;NSC 6701
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Description

CLEAR COLORLESS TO SLIGHTLY BROWN LIQUID

Liquid; PelletsLargeCrystals

Methyl methoxyacetate is a methyl ester.

Methyl methoxyacetate Basic Attributes

Molecular Weight：

104.1

Exact Mass：

104.10

BRN：

1742944

EC Number：

228-539-9

UNII：

N960NQ69LF

NSC Number：

61447|6701

DSSTox ID：

DTXSID3074608

HScode：

29189090

Characteristics

PSA：

35.53000

XLogP3：

0.01

Appearance：

Clear colorless to slightly brown Liquid

Density：

1.0579 g/cm³ @ Temp: 15 °C

Boiling Point：

131 °C

Flash Point：

96 °F

Refractive Index：

1.379

Water Solubility：

H2O: soluble

Storage Conditions：

Flammables area

Safety Information

Packing level：

III

Hazard category：

Transport codes：

UN 3272 3/PG 3

wgk germany：

hazard class code：

safety instructions：

16-29-33

RTECS Number：

AI8910000

Marks：

Precautionary statement(s)：

P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, P501

Hazard Statements：

H226

GHS Classification：

|Warning|H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501|Aggregated GHS information provided by 141 companies from 4 notifications to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

methyl ester of methoxyacetic acid

Methyl methoxyacetate Use and Manufacturing

Methods of Manufacturing

It is derived from methyl chloroacetate and sodium methoxide by methoxylation. Sodium methoxide was added to the reaction pot, and methyl chloroacetate was added with stirring. The temperature was controlled at about 30°C at the beginning, and then kept at about 70°C for the reaction. If the temperature is too high, the color quality of the finished product will be affected; if the temperature is too low, the reaction speed will be too slow. After the feeding is completed, the pH value is measured at the later stage of the reaction. If the pH value is less than 9, sodium methoxide should be added to adjust and the reaction is kept warm until the end. The reaction product distills out methyl methoxyacetate in the desalting pot, and the sodium chloride produced by the reaction remains in the desalting pot.

Uses

Intermediate for pharmaceutical synthesis, mainly used to synthesize weekly effect sulfonamide, vitamin B6, etc.

agro chemical pesticide

Production

500,000 - 1,000,000 lb

Manufacturing Info：

Pesticide, fertilizer, and other agricultural chemical manufacturing|Acetic acid, 2-methoxy-, methyl ester: ACTIVE|PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.

Computed Properties

Molecular Weight:104.10
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:104.047344113
Monoisotopic Mass:104.047344113
Topological Polar Surface Area:35.5
Heavy Atom Count:7
Complexity:60
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Methyl methoxyacetate 6290-49-9

CAS No.: 6290-49-9

Grade: Industrial Grade

Content: 99%

Inquiry