4-Bromophenylacetone
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4-Bromophenylacetone
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CAS No:
6186-22-7
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Formula:
C9H9BrO
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Chemical Name:
4-Bromophenylacetone
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Synonyms:
4-BROMOPHENYLACETONE;4-BROMOPHENYLACETONATE;LABOTEST-BB LT01143429;4-Bromophenylacetone,97%;4-Bromophenylacetone,99%;4-Bromophenylacetone ,98%;P-BROMO BENZYL METHYL KETONE;1-(4-BROMOPHENYL)PROPAN-2-ONE;1-(4-BROMOPHENYL)-2-PROPANONE
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CAS No:
Characteristics
17.1
2.2
clear yellow liquid after melting
1.4±0.1 g/cm3
116-119 °C(lit.)
265.7±15.0°C at 760 mmHg
75.8±7.7 °C
1.546
Miscible with chloroform and dichloromethane. Slightly miscible with water.
4-Bromophenylacetone Use and Manufacturing
A mixture of 1-bromo-4-(2-nitroprop-1-en-1-yl)benzene (116.8 g, 0.48 mol), iron powder(228 g, 4.08 mol) and iron (Ill) chloride (2.28 g, 14 mmol) in water (456 ml) was warmedto 65°C and 37percent hydrochloric acid (ca. 20 ml) added dropwise. Heating was stopped andthe mixture slowly exothermed to ca. 95°C. Once the exotherm had subsided, further37percent HCI (ca. 200 ml) was slowly added and the mixture left to stir to room temperature. Ethyl acetate (900 ml) was then added and the mixture stirred for 30 mm. It was then filtered through a pad of celite and the layers separated; the aqueous was extracted with further ethyl acetate (200 ml) and the combined organics washed with brine and driedover magnesium sulphate. After filteration and concentrated to give 2-(4- bromophenyl)acetone (2044550) as an oil (96.5g (94percent)) which was pure enough to use in the following step.