Hydrogenated MDI

262.35

262.35

225-863-2

6Y80AJA84R|Z717ID22KX|P815VNF99I

2206

DTXSID3027588

Clear, colorless to light-yellow liquid

58.9

6.11 (est)

Clear colorless Liquid

1.07 g/cm³

142-148 °C

156-158 °C @ Press: 0.1 Torr

>230 °F

n20/D 1.497(lit.)

H2O: Insoluble /Reactive

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

(77°F): 0.001 mmHg

Class IIIB Combustible Liquid: Fl.P. at or above 200°F.

Henry's Law constant = 6.78X10-5 atm-cu m/mol at 25 °C (est)

Incompatible with alcohols, amines, bases acids, organotin catalysts; may slowly polymerize if heated above 50 °C; combustible at or above 93.3 °C; freezing point = -10 °C|Specific gravity = 1.07|Reacts with water or ethanol|Hydroxyl radical reaction rate constant = 2.58X10-11 cu cm/molec-sec at 25 °C (est)

Reacts with water to form CO2

Isocyanates and Isothiocyanates

Water-Reactive

Isocyanates and thioisocyanates, such as 1,1-METHYLENE BIS(4-ISOCYANATOCYCLOHEXANE), are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence [Wischmeyer(1969)].

Class IIIB Combustible Liquid: Fl.P. at or above 200°F.

III

6.1

UN 2206 6.1/PG 2

1

23-36/37/38-42/43

26-28-38-45-1/2

NQ9250000

T

May slowly polymerize if heated above 50ºC.

P261-P280-P284-P304 + P340 + P312-P342 + P311-P403 + P233

H315-H317-H319-H331-H334-H335

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Substance reacts with water. ...Dicyclohexylmethan-4,4'-diisocyanate reacts in comparison to hexamethylene diisocyanate very slowly with water and slowly with alcohols or amines; normally the reaction must be catalyzed with metal compounds.|Water, ethanol, alcohols, amines, bases, acids, organotin catalysts (Note: May slowly polymerize if heated above 122 °F.)

Flash point data for this chemical are not available. It is probably combustible. (NTP, 1992)

|Danger|H315: Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P272, P280, P285, P302+P352, P304+P340, P304+P341, P305+P351+P338, P311, P312, P321, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P403+P233, P405, and P501|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P260, P261, P264, P271, P272, P280, P284, P285, P302+P352, P304+P340, P304+P341, P305+P351+P338, P310, P311, P312, P320, P321, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 1130 companies from 30 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|P201, P202, P260, P261, P264, P270, P271, P272, P273, P280, P281, P284, P302+P352, P304+P340, P305+P351+P338, P307+P311, P308+P313, P310, P314, P320, P321, P332+P313, P333+P313, P337+P313, P362, P363, P391, P403+P233, P405, and P501|H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]|P260, P261, P264, P270, P271, P272, P280, P284, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P307+P311, P310, P320, P321, P333+P313, P363, P403+P233, P405, and P501

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Excerpt from ERG Guide 155 [Substances - Toxic and/or Corrosive (Flammable / Water-Sensitive)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)

Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact. Wash skin: The worker should immediately wash the skin when it becomes contaminated. Remove: Work clothing that becomes wet or significantly contaminated should be removed and replaced. Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. Provide: Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.] (NIOSH, 2016)|Respirator Recommendations: Up to 0.1 ppm: [Table#6813]|Respirator Recommendations: Up to 0.25 ppm: [Table#6814]|Respirator Recommendations: Up to 0.5 ppm: [Table#6815]|Respirator Recommendations: Up to 1 ppm: [Table#6816]|For more Personal Protective Equipment (PPE) (Complete) data for METHYLENE BIS(4-CYCLOHEXYLISOCYANATE) (9 total), please visit the HSDB record page.|(See protection codes)

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.|SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|The worker should immediately wash the skin when it becomes contaminated.|Work clothing that becomes wet or significantly contaminated should be removed and replaced.

Recommended Exposure Limit: Ceiling Value: 0.01 ppm (0.11 mg/cu m).

LD50 Rat intravenous 17 mg/kg|LD50 Rat oral 9900 mg/kg|LC50 Rat (male, head only exposure to an aerosol) inhalation 0.295 mg/L/4 hr /Technical grade/|LC50 Rat (female, head only exposure to an aerosol) inhalation 0.307 mg/L/4 hr /Technical grade/|For more Non-Human Toxicity Values (Complete) data for METHYLENE BIS(4-CYCLOHEXYLISOCYANATE) (10 total), please visit the HSDB record page.

Methylene bis(4-cyclohexylisocyanate)'s production and use in the formulation of flexible coatings and polyurethane elastomers(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Isocyanates hydrolyze readily in moist soil(1); therefore, adsorption and volatilization of methylene bis(4-cyclohexylisocyanate) are not expected to be an important environmental fate process(SRC). Methylene bis(4-cyclohexylisocyanate) is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.3X10-5 mm Hg at 25 °C(SRC), determined from a fragment constant method(2). A 0% of theoretical BOD using activated sludge in the Japanese MITI test(3) suggests that biodegradation is an important environmental fate process in soil(SRC).|AQUATIC FATE: Isocyanates hydrolyze readily in water(1); therefore, adsorption to solids and sediment, volatilization and bioconcentration of methylene bis(4-cyclohexylisocyanate) are not expected to be an important environmental fate process(SRC). A 0% of theoretical BOD using activated sludge in the Japanese MITI test(2) suggests that biodegradation is an important environmental fate process in water(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), methylene bis(4-cyclohexylisocyanate), which has an estimated vapor pressure of 2.3X10-5 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase methylene bis(4-cyclohexylisocyanate) is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 5 hours(SRC), calculated from its rate constant of 2.6X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase methylene bis(4-cyclohexylisocyanate) may be removed from the air by wet or dry deposition(SRC). Methylene bis(4-cyclohexylisocyanate) does not contain chromophores that absorb at wavelengths >290 nm(4), and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of methylene bis(4-cyclohexylisocyanate) with photochemically-produced hydroxyl radicals has been estimated as 2.6X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 5 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Isocyanates hydrolyze readily in water to yield a carbamic acid; therefore, hydrolysis of methylene bis(4-cyclohexylisocyanate) is expected to be an important environmental fate process(2). Methylene bis(4-cyclohexylisocyanate) does not contain chromophores that absorb at wavelengths >290 nm(3), and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

Isocyanates hydrolyze readily in water; therefore, bioconcentration of methylene bis(4-cyclohexylisocyanate) is not expected to be an important environmental fate process(1).

Isocyanates hydrolyze readily in moist soil; therefore, adsorption of methylene bis(4-cyclohexylisocyanate) is not expected to be an important environmental fate process(1).

Isocyanates hydrolyze readily in moist soil; therefore, volatilization of methylene bis(4-cyclohexylisocyanate) from water or moist soil surfaces is not expected to be an important environmental fate process(1). Methylene bis(4-cyclohexylisocyanate) is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.3X10-5 mm Hg(SRC), determined from a fragment constant method(2).

According to the 2006 TSCA Inventory Update Reporting data, the number of persons reasonably likely to be exposed in the industrial manufacturing, processing, and use of methylene bis(4-cyclohexylisocyanate) is 100 to 999; the data may be greatly underestimated(1).|NIOSH (NOES Survey 1981-1983) has statistically estimated that 7,764 workers (637 of these were female) were potentially exposed to methylene bis(4-cyclohexylisocyanate) in the US(1). Occupational exposure to methylene bis(4-cyclohexylisocyanate) may occur through inhalation and dermal contact with this compound at workplaces where methylene bis(4-cyclohexylisocyanate) is produced or used(SRC).

Skin sensitization with chemical allergens is associated with the activation and proliferation of lymphocytes in lymph nodes draining the site of exposure. As lymphocyte activation is regulated by the action of cytokines, /the authors have/ investigated the nature and kinetics of cytokine production by draining lymph node cells (LNC) from mice, following their primary exposure to chemical allergens. Both interleukin-1 (IL-1) and IL-6 were induced in a biphasic manner following primary exposure of mice to oxazolone or to dicyclohexylmethane-4,4'-diisocyanate (HMDI). ...Increased IL-4 production was observed only when LNC were prepared 96 hr following sensitization. Despite vigorous lymphocyte proliferation there was no evidence for IL-2 production by draining LNC.

Exposure Routes: inhalation, ingestion, skin and/or eye contact Symptoms: Irritation eyes, skin, respiratory system; skin, respiratory sensitization; chest tightness, dyspnea (breathing difficulty), cough, dry throat, wheezing, pulmonary edema; skin blisters Target Organs: Eyes, skin, respiratory system (NIOSH, 2016)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Generally, the induction of vomiting is NOT recommended outside of a physician's care due to the risk of aspirating the chemical into the victim's lungs. However, if the victim is conscious and not convulsing and if medical help is not readily available, consider the risk of inducing vomiting because of the high toxicity of the chemical ingested. Ipecac syrup or salt water may be used in such an emergency. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)|(See procedures)

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Isocyanates, aliphatic thiocyanates, and related compounds/|Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Monitor for seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 mL of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Isocyanates, aliphatic thiocyanates, and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Treat exposure to Lethane 60 Lethane 384, Thanite, methyl, ethyl, or isopropyl thiocyanates with the cyanide antidote kit. ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Isocyanates, aliphatic thiocyanates, and related compounds/

/SIGNS AND SYMPTOMS/ Exposure of humans to methylene bis(4-cyclohexylisocyanate) has resulted in skin sensitization but only rarely in pulmonary sensitization.|/SIGNS AND SYMPTOMS/ Eleven out of fifteen workers who were first exposed to the substance showed allergic and non-allergic skin reaction. Six suffered from vertigo with and without headaches and four developed a decrease of the obstructive lung function, tachycardia and hypotension (EKG normally).|/CASE REPORTS/ Organic di-isocyanates are used widely in industry. The concomitant respiratory complications are well-known. Cutaneous problems precipitated by skin contact with these chemicals are less well recognized. Allergic contact dermatitis caused by exposure to di-cyclohexylmethane 4,4'-di-isocyanate has been demonstrated in a factory where it was used to form a surface-coating polyurethane. Attention to hygiene methods may have reduced the incidence of cases.|/CASE REPORTS/ The aliphatic diisocyanate dicyclohexylmethane-4,4'-diisocyanate (DMDI) is known to be a strong cutaneous sensitizer. /Investigators/ report a 27-year-old woman who developed a severe eczematous eruption on the arms, trunk, and abdomen within 2 weeks of employment at a company using the product Chem-Dec 808 isocyanate (containing 40-70% weight per weight DMDI). Patch testing was performed with the North American screening series, an isocyanate series, and 1% Chem-Dec 808 isocyanate. At day 7, a +++ reaction to Chem-Dec 808 isocyanate and a ++ reaction to the aromatic isocyanate diphenylmethane-4,4'-diisocyanate were observed. DMDI has strong sensitizing potential and requires rigorous safety monitoring in the workplace.|For more Human Toxicity Excerpts (Complete) data for METHYLENE BIS(4-CYCLOHEXYLISOCYANATE) (6 total), please visit the HSDB record page.

4,4'-diisocyanatodicyclohexylmethane

inhalation, ingestion, skin and/or eye contact

irritation eyes, skin, respiratory system; skin, resp sensitization; chest tightness, dyspnea (breathing difficulty), cough, dry throat, wheezing, pulmonary edema; skin blisters

Eyes, skin, respiratory system

Cyclohexane, 1,1'-methylenebis[4-isocyanato-, (trans,trans)-: INACTIVE|PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.|Adhesive manufacturing|Cyclohexane, 1,1'-methylenebis[4-isocyanato-: ACTIVE

Method: NIOSH 5525, Issue 1; Procedure: high performace liquid chromatography, ultraviolet/fluorescence detection; Analyte: MAP (1-(9-anthracenylmethyl)piperazine) derivatives of isocyanates; Matrix: air; Detection Limit: 0.2 nmole NCO per species per sample (0.2 nmole NCO equals 0.017 ug HDI per sample).|Method: OSHA PV2092; Procedure: high performance liquid chromatography using an ultraviolet or fluorescence detector; Analyte: methylene bis(4-cyclohexylisocyanate); Matrix: air; Detection Limit: 0.4 ug/cu m.