Amodiaquine dihydrochloride dihydrate
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Amodiaquine dihydrochloride dihydrate
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CAS No:
6398-98-7
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Formula:
C20H22ClN3O.2ClH.2H2O
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Chemical Name:
Amodiaquine dihydrochloride dihydrate
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Synonyms:
Phenol,4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-,hydrochloride,hydrate (1:2:2);o-Cresol,4-[(7-chloro-4-quinolyl)amino]-α-(diethylamino)-,dihydrochloride,dihydrate;Phenol,4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-,dihydrochloride,dihydrate;Amodiaquin dihydrochloride dihydrate;Amodiaquine dihydrochloride dihydrate
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CAS No:
Description
Amodiaquine dihydrochloride dihydrate is a histamine N-methyltransferase inhibitor, used as an antimalarial and anti-inflammatory agent.Target: histamine N-methyltransferaseAmodiaquine has been shown to be more effective than chloroquine in treating chloroquine-resistant Plasmodium falciparum malaria infections and may afford more protection than chloroquine when used as weekly prophylaxis. Amodiaquine is generally well tolerated.
Amodiaquine Hydrochloride is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties. Similar in structure and activity to chloroquine, amodiaquine is effective against some chloroquine-resistant strains, particularly Plasmodium falciparum, the most deadly malaria parasite. Although the mechanism of plasmodicidal action has not been fully elucidated, like other quinoline derivatives, amodiaquine likely is able to inhibit heme polymerase activity in the body. This results in accumulation of free heme, which is toxic to the parasites.|A 4-aminoquinoline compound with anti-inflammatory properties.
Amodiaquine dihydrochloride dihydrate Basic Attributes
428.78
463.12
200-706-0
K6PW2S574L
DTXSID3045568
C65232
2933492250
Safety Information
NONH for all modes of transport
3
GO7300100
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 18 companies from 1 notifications to the ECHA C&L Inventory.|H302 (75%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 4 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585) (See all compounds classified as Antimalarials.)
Amodiachin
Amodiaquine dihydrochloride dihydrate Use and Manufacturing
antimalarial
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:464.8
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:463.119625
Monoisotopic Mass:463.119625
Topological Polar Surface Area:50.4
Heavy Atom Count:29
Complexity:406
Covalently-Bonded Unit Count:5
Compound Is Canonicalized:Yes
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Amodiaquine dihydrochloride dihydrate
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