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Chlorprothixene hydrochloride

Chlorprothixene hydrochloride structure

CAS No:
6469-93-8
Formula:
C18H18ClNS.ClH
Chemical Name:
Chlorprothixene hydrochloride
Synonyms:
1-Propanamine,3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-,hydrochloride (1:1),(3Z)-;Thioxanthene-Δ9,γ-propylamine,2-chloro-N,N-dimethyl-,hydrochloride,(Z)-;1-Propanamine,3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-,hydrochloride,(Z)-;1-Propanamine,3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-,hydrochloride,(3Z)-;9H-Thioxanthene,1-propanamine deriv.;Truxal hydrochloride;cis-Chlorprothixene hydrochloride;Chlorprothixene hydrochloride;NSC 169899
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

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Description

Pale Yellow Solid

Chlorprothixene hydrochloride Basic Attributes

Molecular Weight：

352.32

Exact Mass：

351.06200

EC Number：

229-289-3

Characteristics

PSA：

28.54000

XLogP3：

5.99000

Appearance：

White powder

Melting Point：

207.5-208 °C

Boiling Point：

461.8ºC at 760 mmHg

Flash Point：

233.1ºC

Water Solubility：

soluble in water and in alcohol, slightly soluble in methylene chloride.

Storage Conditions：

2-8°C

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

20/21/22

safety instructions：

RTECS Number：

XO0610000

Marks：

Precautionary statement(s)：

Missing Phrase - N15.00950417

Hazard Statements：

H301

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 40 companies from 2 notifications to the ECHA C&L Inventory.

Chlorprothixene hydrochloride Use and Manufacturing

Neuroleptic;D2 dopamine receptor antagonist

Computed Properties

Molecular Weight:352.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:351.0615262
Monoisotopic Mass:351.0615262
Topological Polar Surface Area:28.5
Heavy Atom Count:22
Complexity:381
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It can improve mental disorders by blocking postsynaptic dopamine receptors in the brain, inhibit the ascending activation system of the brainstem reticular formation, cause sedation, and inhibit the medulla chemoreceptor area to exert an antiemetic effect. This product has weak anti-adrenergic and anti-cholinergic effects, and has anti-depressant and anti-anxiety effects.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Chlorprothixene Hydrochloride Injection
Ingredients	The main ingredient of this product is chlorprothixene hydrochloride, and its chemical name is: (Z) N, N-dimethyl-3-(2-chloro-9H-thioxanthenyl)-1-propylamine hydrochloride.
Indication	1. This product can enhance the efficacy of central nervous system depressants such as inhaled general anesthetics or intravenous general anesthetics such as barbiturates. When used together, the dosage of central nervous system depressants should be reduced to 1/4~1/2 of the usual dosage. 2. This product can reduce the effect of amphetamine when used in combination. 3. When used in combination with gastric acid suppressants or laxatives, the absorption of this product can be reduced. 4. This product can lower the seizure threshold and weaken the effect of anticonvulsants. It is not suitable for patients with epilepsy. 5. When this product is used in combination with anticholinergic drugs, the efficacy can be mutually enhanced. 6. When this product is used in combination with adrenaline, due to the blockage of α receptor activity and the dominance of β receptor activity, a drop in blood pressure may occur. <br
Specifications	2ml:30mg

Recommended Suppliers of Chlorprothixene hydrochloride

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Chlorprothixene hydrochloride

CAS No.: 6469-93-8

Content: 99.00%

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Guide of Chlorprothixene hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Recommended Suppliers
Latest News
Learn More Other Chemicals

Chlorprothixene hydrochloride

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