Nimorazole
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Nimorazole
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CAS No:
6506-37-2
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Formula:
C9H14N4O3
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Chemical Name:
Nimorazole
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Synonyms:
Morpholine,4-[2-(5-nitro-1H-imidazol-1-yl)ethyl]-;Morpholine,4-[2-(5-nitroimidazol-1-yl)ethyl]-;4-[2-(5-Nitro-1H-imidazol-1-yl)ethyl]morpholine;1-(β-Morpholinoethyl)-5-nitroimidazole;Nitrimidazine;Nimorazole;4-[2-(5-Nitroimidazol-1-yl)ethyl]morpholine;Naxogin;K-1900;Nimorazol;Naxofem;Nulogyl;Acterol;Esclama;NSC 107524;1-(Morpholinoethyl)-5-nitroimidazole
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CAS No:
Description
Nimorazole (K-1900) is a nitroimidazole anti-infective.
Nimorazole is a member of imidazoles and a C-nitro compound.|Nimorazole has been used in trials studying the treatment of Hypoxia, Radiotherapy, Hypoxic Modification, Gene Profile, Gene Signature, and Head and Neck Squamous Cell Carcinoma, among others.|Nimorazole is a water soluble, 5-nitroimidazole compound with antibacterial and potential radiosensitizing activity. As an oxygen mimetic, nimorazole induces free radical formation and is able to sensitize hypoxic cells to the cytotoxic effects of ionizing radiation. This prevents DNA repair and thus enhances damage to DNA strands; eventually, leading to tumor cell death. Nimorazole is less active but also less toxic than the 2-nitroimidazole compounds, misonidazole and etanidazole.|An antitrichomonal agent which is effective either topically or orally and whose urinary metabolites are also trichomonicidal.
Nimorazole Basic Attributes
226.236
226.23
229-394-4
469ULX0H4G
107524
DTXSID1057795
C76425
P - Antiparasitic products, insecticides and repellents
2934999090
Characteristics
76.1
-0.4
1.4±0.1 g/cm3
110-111 °C
443.0±35.0°C at 760 mmHg
221.7±25.9 °C
1.637
LD50 orally in mice: 1530 mg/kg (Cavalleri)
Safety Information
Ⅲ
3077
9
P201, P202, P260, P263, P264, P270, P281, P301+P312, P308+P313, P330, P405, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P263, P264, P270, P281, P301+P312, P308+P313, P330, P405, and P501|Aggregated GHS information provided by 30 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Agents used to treat trichomonas infections. (See all compounds classified as Antitrichomonal Agents.)
Esclama
Nimorazole Use and Manufacturing
Nimorazole is an antimicrobial with activity against anaerobic bacteria and protozoa.
Human drugs -> Rare disease (orphan)|Pharmaceuticals
Computed Properties
Molecular Weight:226.23
XLogP3:-0.4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:226.10659032
Monoisotopic Mass:226.10659032
Topological Polar Surface Area:76.1
Heavy Atom Count:16
Complexity:239
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
