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Sodium diatrizoate

Sodium diatrizoate structure

CAS No:
737-31-5
Formula:
C11H9I3N2O4.Na
Chemical Name:
Sodium diatrizoate
Synonyms:
Benzoic acid,3,5-bis(acetylamino)-2,4,6-triiodo-,sodium salt (1:1);Benzoic acid,3,5-diacetamido-2,4,6-triiodo-,monosodium salt;Benzoic acid,3,5-bis(acetylamino)-2,4,6-triiodo-,monosodium salt;Benzoic acid,3,5-diacetamido-2,4,6-triiodo-,sodium salt;Diatrizoate sodium;Hypaque;Hypaque sodium;Sodium amidotrizoate;Sodium 3,5-diacetamido-2,4,6-triiodobenzoate;Sodium diatrizoate;Triombrine;Triombrin;Hypaque 50;3,5-Diacetamido-2,4,6-triiodobenzoic acid sodium salt;Urografic acid sodium salt;Radioselectan;Urografin S;Urovist 300;Urographing 370;Urovist sodium;Urovist sodium 300
Categories:
Active Pharmaceutical Ingredients > Diagnostic Agents

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Description

Sodium diatrizoate is an iodinated radiocontrast agent.

Sodium diatrizoate Basic Attributes

Molecular Weight：

635.9

Exact Mass：

635.751587

EC Number：

212-004-1

HScode：

2924299090

Characteristics

PSA：

98.3

XLogP3：

log Kow = -1.28 (est)

Appearance：

White Powder

Melting Point：

261 °C

Boiling Point：

614.1ºC at 760 mmHg

Flash Point：

325.2ºC

Water Solubility：

H2O: 0.35 g/mL, slightly turbid, colorless

Storage Conditions：

Refrigerate the product upon receipt at 2 deg C to 8 deg C.

Toxicity：

Oral-rat LD50: > 7000 mg/kg; Oral-Mouse LD50: > 7000 mg/kg

Flammability characteristics：

Open flame is flammable; heat releases toxic nitrogen oxide, sodium oxide, iodide gas

Taste：

Slightly salty taste

PH：

pH of 50% aqueous solution 7.0 to 7.5

Safety Information

Packing level：

Ⅲ

Transport codes：

2811

wgk germany：

hazard class code：

42/43

safety instructions：

RTECS Number：

DG6125000

Marks：

Storage features：

Warehouse ventilated, low temperature and dry

Precautionary statement(s)：

P261-P280-P284-P304 + P340-P342 + P311

Hazard Statements：

H317-H334

Toxicity

Toxicity class：

nontoxic

Sodium diatrizoate Use and Manufacturing

Water-soluble contrast agent, commonly used for urography, but also for renal, cardiovascular, cerebrovascular, etc.

Drug Function and Efficacy

This product is a diagnostic drug. The sodium ion concentration of its 76% solution is about 136mmol/L, which is close to the concentration in plasma and has little effect on myocardial cell function. Sodium diatrizoate is an ionic monomer iodine contrast agent. Iodine can absorb a large amount of X-rays. After being injected into the body, it forms a density contrast with the surrounding tissues under X-rays and develops. When using the direct introduction method for contrast imaging, it can be directly injected into the blood vessels or other cavities to show the luminal morphology. When using the physiological absorption method for contrast imaging, the contrast agent injected into the blood vessels can enter the diseased tissue through the damaged vascular endothelium or the damaged blood-brain barrier to show the lesions. The urinary tract morphology can be displayed when excreted through the kidneys.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Compound diatrizoate meglumine injection
Ingredients	60% contains 292mg/ml iodine, and 76% contains 370mg/ml iodine.
Indication	1. Intravascular injection of this product immediately after taking cholecystography contrast agent will increase the toxic effect on the kidneys, especially in patients with impaired liver function. 2. Although the use of vasopressors during aortic angiography can improve the contrast of the imaging, due to the contraction of visceral blood vessels, a large amount of contrast agent is forced to enter the spinal cord blood vessels, which increases the neurotoxicity of this product and may cause paraplegia. 3. This product should not be mixed with antihistamines for injection. It may precipitate when mixed with promethazine hydrochloride, diphenhydramine hydrochloride, chlorpheniramine maleate (chlorpheniramine), etc.
Specifications	20ml:15.2g (with 1ml:0.3g test needle)
Manufacturer	Jinling Pharmaceutical Co.,ltd.zhejiang Tianfeng Pharmaceutical FACTORY

Compound diatrizoate meglumine injection
Ingredients	60% contains 292mg/ml iodine, and 76% contains 370mg/ml iodine.
Indication	1. Intravascular injection of this product immediately after taking cholecystography contrast agent will increase the toxic effect on the kidneys, especially in patients with impaired liver function. 2. Although the use of vasopressors during aortic angiography can improve the contrast of the imaging, due to the contraction of visceral blood vessels, a large amount of contrast agent is forced to enter the spinal cord blood vessels, which increases the neurotoxicity of this product and may cause paraplegia. 3. This product should not be mixed with antihistamines for injection. It may precipitate when mixed with promethazine hydrochloride, diphenhydramine hydrochloride, chlorpheniramine maleate (chlorpheniramine), etc.
Specifications	Calculated based on the total amount of diatrizoate meglumine and diatrizoate sodium: 20ml: 15.2g
Manufacturer	Wuxi Jiyu Shanhe Pharmaceutical Co., Ltd.

Compound diatrizoate meglumine injection
Ingredients	This product is a compound preparation, and its components are: 1 part of sodium diatrizoate and 6.6 parts of diatrizoate meglumine plus an appropriate amount of sodium hydroxide to make a sterile aqueous solution, and the total amount of sodium diatrizoate (C11H8I3N2NaO4) and diatrizoate meglumine (C11H9I3N2O4C7H17NO5) should be 90.0%-110.0% of the labeled amount. Each injection contains 32mg of sodium diatrizoate and 268mg of diatrizoate meglumine.
Indication	1. Intravascular injection of this product immediately after taking cholecystography contrast agent will increase the toxic effect on the kidneys, especially in patients with impaired liver function. 2. Although the use of vasopressors during aortic angiography can improve the contrast of the imaging, due to the contraction of visceral blood vessels, a large amount of contrast agent is forced to enter the spinal cord blood vessels, which increases the neurotoxicity of this product and may cause paraplegia. 3. This product should not be mixed with antihistamines for injection. It may precipitate when mixed with promethazine hydrochloride, diphenhydramine hydrochloride, chlorpheniramine maleate (chlorpheniramine), etc.
Specifications	20ml:12g based on the total amount of diatrizoate meglumine and diatrizoate sodium
Manufacturer	Shanghai Xudong Haipu Pharmaceutical Co., Ltd.

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Registered Holders

HONOUR LAB LTD

United States
Active
BIOPHORE INDIA PHARMACEUTICALS PVT LTD

United States
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Vasudha Pharma Chem Ltd

United States
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