Tris(2-butoxyethyl) phosphate

398.47200

398.47

201-122-9

RYA6940G86

62228|4839

DTXSID5021758

Liquid|Light-colored liquid|Slightly yellow, oily liquid

2920901900

82.26000

4.59440

Tributoxyethyl phosphate is a slightly yellow viscous liquid. (NTP, 1992)

1.020 g/cm³ @ Temp: 20 °C

-70 °C

215-228 °C @ Press: 4 Torr

223ºC

1.437-1.439

H2O: soluble

Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from

0.03 mm Hg ( 150 °C)

13.7 (vs air)

LD50 oral in rat: 3gm/kg

SWEETISH

Henry's Law constant = 1.2X10-11 atm-cu m/mol at 25 °C (est)

196.44 Ų [M+H]+

Hydroxyl radical reaction rate constant = 1.2X10-10 cu cm/molec-sec at 25 °C (est)

Water soluble.

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

Organophosphates, such as TRIBUTOXYETHYL PHOSPHATE, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides. This material may react with oxidizers. (NTP, 1992).

NONH for all modes of transport

1

R20/21/22; R36/37/38

S26-S37/39

KJ9800000

Xn

Stable. Combustible. Incompatible with strong oxidizing agents.

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, P501

H302

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.|Waste treatment methods. Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging: Dispose of as unused product.

Can react with oxidizing materials.|Incompatible materials: Strong oxidizing agents, strong oxidizing agents, strong bases.

Tributoxyethyl phosphate is an indirect food additive for use only as a component of adhesives.

This chemical is combustible. (NTP, 1992)

|Warning|H302 (27.43%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 531 companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H317: May cause an allergic skin reaction [Warning Sensitization, Skin]|P261, P272, P280, P302+P352, P321, P333+P313, P363, and P501|H312: Harmful in contact with skin [Warning Acute toxicity, dermal]|P261, P264, P271, P273, P280, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this chemical under refrigerated temperatures, and keep it away from oxidizing materials. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)|Respiratory protection (supplied-air respirator with full facepiece or self-contained breathing apparatus) should be available where these compounds are manufactured or used and should be worn in case of emergency and overexposure. /Phosphorus compounds/|Eye/face protection: Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).|Skin protection: Handle with gloves.|Body Protection: Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.|Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multipurpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Combustible when exposed to heat or flame.|COMBUSTIBLE

To fight fire: water, foam, carbon dioxide, dry chemical.|Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.|Advice for firefighters: Wear self contained breathing apparatus for fire fighting if necessary.

Accidental Release Measures. Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|Precautions for safe handling: Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. Normal measures for preventive fire protection.|Appropriate engineering controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.|Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

A skin and eye irritant.

The concentration ranges of tri(2-butoxyethyl) phosphate in 5 effluents which directly discharge wastewater into the River Weser, Germany were 1260-3370, 800-2750, 2920-5299, 980-34900 and 12-836 ng/L, resulting in the discharged amount of 176-472, 12.8-44, 14.7-26.6, 19-687 and 0-2.3 g/day at the 5 locations, respectively(1). Effluent wastewater samples collected in July 2001 from three municipal sewage treatment plants and one industrial sewage treatment plant that discharge their treated wastewater into the Oder River in Germany had mean tri(2-butoxyethyl) phosphate concentrations of 2955 ng/L and 162 ng/L, respectively(2). The concentration of tri(2-butoxyethyl) phosphate in sludge samples taken from 11 sewage treatment plants located throughout Sweden was <5.1-1900 ng/g dry weight, samples were collected 2002 to 2003(3). The concentration of tri(2-butoxyethyl) phosphate in influent and effluent samples taken concurrently from these same plants was 5200-35,000 and 3100-30,000 ng/L, respectively(3). Tri(2-butoxyethyl) phosphate was detected at median values of 0.70-0.87 ug/L in influent samples and median concentration of 0.55 ug/L in effluent samples from three waste water treatment plants located in Galicia, Spain; samples were collected Nov 2007, Feb, Jun and Sep 2008(4).

Nine organophosphorus flame retardants (PFRs) were detected in a pelagic and benthic food web of the Western Scheldt estuary, The Netherlands. Concentrations of several PFRs were an order of magnitude higher than those of the brominated flame retardants (BFRs). However, the detection frequency of the PFRs (6-56%) was lower than that of the BFRs (50-97%). Tris(2-butoxyethyl) phosphate (TBOEP), tris(isobutyl) phosphate (TIBP) and tris(2-chloroisopropyl) phosphate (TCIPP) were the dominant PFRs in sediment with median concentrations of 7.0, 8.1 and 1.8 ng/g dry weight (dw), respectively. PFR levels in the suspended particular matter (SPM) were 2-12 times higher than that in sediment. ...

URBAN/SUBURBAN: Tri(2-butoxyethyl) phosphate was detected at <1.6 pg/cu m in Pallas, Finland; samples were collected Jul 2004(1).|Atmospheric particulate samples collected Mar to Dec 2012 from 5 sites located in the Great Lakes basin contained tri(2-butoxyethyl) phosphate at the following average concentrations(1):[Table#4046]|INDOOR AIR: Tri(2-butoxyethyl) phosphate was identified in association with office airborne particles and its representative indoor concentration is 15.0 ng/cu m(1). Tri(2-butoxyethyl) phosphate was below the detection limit (<0.1 ng/cu m) in indoor air from a computerized office environment(2). Tri(2-butoxyethyl) phosphate was detected at <4X10-5 to 0.3 ug/cu m in the indoor air from 6 Japanese homes(3). Tri(butoxyethyl) phosphate was not detected in an atmospheric sample collected from a theater in Zurich, Switzerland(4).

Atmospheric particulate samples collected Mar to Dec 2012 from 5 sites located in the Great Lakes basin contained tri(2-butoxyethyl) phosphate at the following average concentrations(1):[Table#4051]|The atmospheric deposition of tri(2-butoxyethyl) phosphate was calculated to be <0.8 ng/sq m/day in samples from Pallas, Finland; samples were collected Jul 2004(1). Tri(butoxyethyl) phosphate was not detected in three cars; samples were collected in Zurich, Switzerland(2).

IDENTIFICATION AND USE: Tri (2-butoxyethyl) phosphate (TBEP) is a slightly yellow, oily liquid. It is used as a fire-resistant and light stable plasticizer in the production of vinyl resins, rubber, nitrocellulose and cellulose acetate, and synthetic rubber intended for contact with food or drink. HUMAN EXPOSURE AND TOXICITY: A repeat human insult patch test indicated no skin sensitization and minimal skin irritation. ANIMAL STUDIES: The acute systemic mammalian toxicity and irritation potential are low. Several subchronic studies in laboratory animals have shown that the liver is the target organ. One study in male Sprague-Dawley rats suggested that TBEP might cause focal myocarditis. In neurotoxicity studies in hens TBEP had no effect on neuropathy target esterase (NTE). Brain and plasma cholinesterases were inhibited in treated hens. Neurotoxicity studies in rats demonstrated degenerative changes in both myelinated and unmyelinated fibers of female and male animals. Although similar morphological changes were observed in both genders, females were more susceptible than males to the toxic effects of this compound. TBEP also induced electrophysiologic changes in sciatic nerves from rats. The long term toxicity and carcinogenicity of TBEP have not been studied. TBEP causes toxicity in the developing zebrafish by inhibiting the degradation and utilization of nutrients from the mother and inducing apoptosis. Teratogenicity was not observed. The compound is absorbed dermally in experimental animals but no information is available on its kinetics and metabolism. A mutagenicity test in Salmonella typhimurium strains TA1535, TA1538, TA1537, TA98 and TA100, with and without metabolic activation was negative. ECOTOXICITY STUDIES: The toxicity of TBEP to aquatic organisms is moderate.

LD50 Rat oral 3,000 mg/kg|LD50 Mouse intravenous 180 mg/kg|LD50 Guinea Pig oral 3,000 mg/kg

/BIRDS and MAMMALS/ Nine organophosphorus flame retardants (PFRs) were detected in a pelagic and benthic food web of the Western Scheldt estuary, The Netherlands. Concentrations of several PFRs were an order of magnitude higher than those of the brominated flame retardants (BFRs). ...

Tri(2-butoxyethyl) phosphate's production and use as a plasticizer in most resins and elastomers, in floor finishes and waxes and as a flame-retarding agent(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1260(SRC), determined from a structure estimation method(2), indicates that tri(2-butoxyethyl) phosphate is expected to have low mobility in soil(SRC). Volatilization of tri(2-butoxyethyl) phosphate from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.2X10-11 atm-cu m/mole(SRC), using a fragment constant estimation method(2). Tri(2-butoxyethyl) phosphate is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.2X10-6 mm Hg at 25 °C(SRC), determined from a fragment constant method(2). Utilizing the Japanese MITI test, 0% of the theoretical BOD was reached in 4 weeks(3) indicating that biodegradation is not an important environmental fate process(SRC). However, in river die-away studies tri(2-butoxyethyl) phosphate degraded 100% in 30 days in one of three experiments(4).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1260(SRC), determined from a structure estimation method(2), indicates that tri(2-butoxyethyl) phosphate is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 1.2X10-11 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). Tri(2-butoxyethyl) phosphate may undergo environmental hydrolysis based on estimated half-lives of 93-95 days at pH 9-5(2). According to a classification scheme(4), experimental BCFs of <5.8 and <0.6-4.1 in carp(5), suggest bioconcentration in aquatic organisms is low(SRC). Studies have shown that tri(2-butoxyethyl) phosphate can be degraded in environmental conditions, however the mode of degradation may be unclear(6-7). Tri(2-butoxyethyl) phosphate degraded 100% in 80 days aerobic pond water and pond water with sediment, but also degraded 20-75% in 80 days in sterilized experiments(6).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tri(2-butoxyethyl) phosphate, which has an estimated vapor pressure of 1.2X10-6 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase tri(2-butoxyethyl) phosphate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 3 hours(SRC), calculated from its rate constant of 1.2X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Particulate-phase tri(2-butoxyethyl) phosphate may be removed from the air by wet and dry deposition(SRC). Tri(2-butoxyethyl) phosphate does not contain chromophores that absorb at wavelengths >290 nm(3) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of tri(2-butoxyethyl) phosphate with photochemically-produced hydroxyl radicals has been estimated as 1.2X10-10 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 3 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Tri(2-butoxyethyl) phosphate may undergo hydrolysis in the environment(SRC) based on estimated hydrolysis half-lives of 95-93 days at pH 5 to 9(1). Tri(2-butoxyethyl) phosphate does not contain chromophores that absorb at wavelengths >290 nm(2) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

5.75|BCFs of <5.8 and <0.6-4.1 were reported in carp (Cyprinus carpio) which were exposed to tri(2-butocyethyl) phosphate at 0.02 and 0.2 ppb, respectively, over a 6-week period(1). According to a classification scheme(2), these BCFs suggest bioconcentration in aquatic organisms is low(SRC).|Nine organophosphorus flame retardants (PFRs) were detected in a pelagic and benthic food web of the Western Scheldt estuary, The Netherlands. Concentrations of several PFRs were an order of magnitude higher than those of the brominated flame retardants (BFRs). However, the detection frequency of the PFRs (6-56%) was lower than that of the BFRs (50-97%). ... Tris(2-butoxyethyl) phosphate (TBOEP), tris(2-chloroisopropyl) phosphate (TCIPP) , tris(isobutyl) phosphate (TIBP), tris(2-chloroethyl) phosphate (TCEP) and tris(phenyl) phosphate (TPHP) were found in organisms higher in the estuarine food web. ... Indications of trophic magnification of PFRs were observed in the benthic food web for TBOEP, TCIPP and TCEP with tentative trophic magnification factors of 3.5, 2.2 and 2.6, respectively (p<0.05). Most of the other PFRs showed trophic dilution in both food webs. The relative high PFR levels in several fish species suggest high emissions and substantial exposure of organisms to PFRs in the Western Scheldt.

Using a structure estimation method based on molecular connectivity indices(1), the Koc of tri(2-butoxyethyl) phosphate can be estimated to be 1260(SRC). According to a classification scheme(2), this estimated Koc value suggests that tri(2-butoxyethyl) phosphate is expected to have low mobility in soil.

The Henry's Law constant for tri(2-butoxyethyl) phosphate is estimated as 1.2X10-11 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that tri(2-butoxyethyl) phosphate is expected to be essentially nonvolatile from moist soil and water surfaces(2). Tri(2-butoxyethyl) phosphate is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.2X10-6 mm Hg(SRC), determined from a fragment constant method(1).

GROUNDWATER: Tri(2-butoxyethyl) phosphate was detected with a mean concentration (76 samples) of 410 ng/L in groundwater samples from Nieschen, Germany collected in March 2000, November 2000, and March 2001. Groundwater samples collected at distances of 4.5, 604, 3000, and 5000 m from the Oder River in Germany contained tri(2-butoxyethyl) phosphate concentrations of 339, 126, 1611 ng/L and not detected, respectively. The concentrations of tri(2-butoxyethyl) phosphate in groundwater samples from a multilevel monitoring well in Bahnbrucke, Germany sampled in March 2001 were 109, 122, 85, 91 and 85 ng/L at depths of 3, 7, 11, 17 and 21 m, respectively(1).|DRINKING WATER: Tri(2-butoxyethyl) phosphate was detected in municipal drinking water supplies drawn from 33 different locations in 29 Canadian cities at 1.1-560 ng/L between August and December 1979(1). Tri(2-butoxyethyl) phosphate was detected in municipal drinking water supplies in Selkirk, Manitoba during October and November 1979 at 390 and 38 ng/L, respectively(1). Tri(2-butoxyethyl) phosphate was quantitatively detected in drinking water from 6 eastern Ontario water treatment plants during June, September, and October 1978 at 0.9-75.4 ng/L with an average concentration of 21 ng/L(2). In 1980, tri(2-butoxyethyl) phosphate was detected in drinking water samples from 12 Great Lakes municipal drinking water supplies at 1.6-271.6 ng/L(3). Tri(2-butoxyethyl) phosphate was detected at 7.7 and 13.7 ng/L in 2 samples taken in January and July 1980, respectively, from a municipal drinking water supply in Thunder Bay, Ontario(3). In a study conducted Nov to Dec 2001 by the US Geological Survey and the Center For Disease Control and Prevention, drinking water samples derived from two low flow streams contained a maximum tri(2-butoxyethyl) phosphate concentration of 0.35 ug/L(4). Tri(2-butoxyethyl) phosphate was not detected (detection limit 3 ng/L) in the finished water samples from three water treatment plants along the Ruhr River, Germany(5).|SURFACE WATER: Tri(2-butoxyethyl) phosphate was detected in 45.9% of 85 samples taken from streams across the United States between 1999-2000(1); the maximum and median concentrations were 6.7 and 0.51 ug/L, respectively(1). Tri(2-butoxyethyl) phosphate was identified in Delaware river water samples taken in August 1976 at a range of 0.4 to 2 ppb and in March 1977 at a range of 0.03 to 3 ppb(2). Tri(2-butoxyethyl) phosphate was detected in three samples from two sites on the Assunpink Creek, Trenton, NJ at 88-460 and 90-170 ng/L(3) Tri(2-butoxyethyl) phosphate was not detected (detection limit 0.13 ng/POCIS sample (polar organic chemical integrative sampler)) in six cave rivers located in northeastern Oklahoma and northwestern Arkansas, not detected in Little Osage Creek, AR, but was detected in an unnamed creek in Oklahoma at 1450 ng/POCIS sample; samples were taken May to July 2006(4). Tri(2-butoxyethyl) phosphate was not detected (detection limit 0.5 ug/L) in samples collected from 18 sites on seven streams in north central Arkansas(5). Tri(2-butoxyethyl) phosphate was detected with a frequency of 13.6, 4.3 and 26.7% at a maximum concentration of 0.14, 0.12 and 0.87 ug/L in 23, 23 and 30 high, normal and low-flow stream water samples, respectively of 10 cities in Iowa in 2001(6).|SURFACE WATER: Tri(2-butoxyethyl) phosphate was identified in river water in Osaka City, Japan at 0.331-1.94 ug/L(1). In 1988, the concentration of tri(2-butoxyethyl) phosphate in the Nilwala River in southern Sri Lanka ranged from 400 to 500 ng/L; the concentration in the River Weser, Germany was 130 ng/L(2). For samples taken 1989 and 1990, tri(2-butoxyethyl) phosphate concentrations in the Yodo river, rivers in Osaka City, Yamato river and Osaka Bay were approximately 0.3, 2.7, 1.8 and 0.1 ug/L, respectively(3). Tri(2-butoxyethyl) phosphate was detected in the Ruhr River, Germany at 140-170 ng/L in samples collected at entry points for 3 water treatment plants(4). Surface water samples from tributaries that empty into the North Sea contained tri(2-butoxyethyl) phosphate at less than detection limit (

As part of FDA Market Basket Study between 1982 and 1991, tri(2-butoxyethyl) phosphate was detected in 5 ready-to-eat foods at an average concentration of 0.28 ug/g(1).

The flame retardant tris(2-butoxyethyl) phosphate (TBEP) is a frequently detected contaminant in the ... human milk. ...

According to the 2006 TSCA Inventory Update Reporting data, the number of persons reasonably likely to be exposed in the industrial manufacturing, processing, and use of tri(2-butoxyethyl) phosphate is 100-999; the data may be greatly underestimated(1).|NIOSH (NOES Survey 1981-1983) has statistically estimated that 257,421 workers (105,777 of these are female) were potentially exposed to tri(2-butoxyethyl) phosphate in the US(1). Occupational exposure to tri(2-butoxyethyl) phosphate may occur through inhalation and dermal contact with this compound at workplaces where tri(2-butoxyethyl) phosphate is produced or used. Monitoring data indicate that the general population may be exposed to tri(2-butoxyethyl) phosphate via inhalation of ambient air, ingestion of food and drinking water, and dermal contact with this compound or other products containing tri(2-butoxyethyl) phosphate(SRC).|Tri(2-butoxyethyl) phosphate concentrations were sampled in different occupational media; results included: inhalable air <50-<60 ng/cu m, particulates <20-<40 ng/cu m, absorbent patches <0.5 ng sq m and hand wash samples <10 ng/hands(1). Tri(2-butoxyethyl) phosphate was detected in the air of a recycling electronic products plant at 20-36 ng/cu m in the dismantling hall, 17-19 ng/cu m in shredder during processing of plastics without brominated additives, and 20-24 ng/cu m in the shredder during processing of plastics containing brominated additives(2). Tri(butoxyethyl) phosphate was not detected in 3 electronic stores but was detected in 1 of 3 offices and 1 of 2 furniture stores; concentrations were below reporting level; all samples were collected in and around Zurich, Switzerland(3).

Plasticizer tributoxyethyl phosphate was identified in post-mortem blood sample. Presence of plasticizers in blood samples can arise by contamination from rubber stopper of blood specimen containers.|Tri(2-butoxyethyl) phosphate was detected in 20 of 58 adipose tissue samples taken from Kingston, Ontario at 0.7-26.8 ng/g. It was also detected in 21 of 57 adipose tissue samples taken from Ottawa, Ontario at 0.9-142.2 ng/g(1).|Adipose tissue samples collected from cadavers in six Ontario, Canada municipalities had the following tri(2-butoxyethyl) phosphate concentrations(1):[Table#4049]

Most organophosphate compounds are ... absorbed from skin, gastrointestinal tract, & lung.|Products of hydrolysis (by plasma and tissue enzymes) were excreted in urine. Oxidation was also involved in the metab.

Products of hydrolysis (by plasma and tissue enzymes) were excreted in urine. Oxidation was also involved in the metab.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

/SRP:/ Immediate first aid: Remove patient from contact with the material. Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Inorganic Bases/Alkaline Corrosives and Related Compounds/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 6 to 12 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool ... . Do not attempt to neutralize. Cover skin burns with dry sterile dressings after decontamination ... . /Inorganic Bases/Alkaline Corrosives and Related Compounds/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Early intubation, at the first signs of upper airway obstruction, may be necessary. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Inorganic Bases/Alkaline Corrosives and Related Compounds/

/HUMAN EXPOSURE STUDIES/ A repeat human insult patch test on a panel of 209 volunteers was undertaken ... in the 3 week induction period, four applications per week of 0.2 ml of the test material were applied for 24 hr to occluded skin. During the fourth week, four similar applications were made to previously untreated sites. During induction, minimal irritation was observed in 9 of the individuals. The irritation was only seen once or twice during the 12 applications. There was no dermal reaction to challenge applications. The results indicate minimal skin irritation and do not indicate any sensitizing potential.

tributoxyethyl phosphate

Paint and coating manufacturing|Ethanol, 2-butoxy-, 1,1',1''-phosphate: ACTIVE|Light stability very high but it has a strong tendency to migrate; can be corrected by blending with other plasticizers.

Method: USGS-NWQL O-1433-01; Procedure: gas chromatography/mass spectrometry; Analyte: tri(2-butoxyethyl) phosphate; Matrix: filtered wastewater and natural-water samples; Detection Limit: 0.2 ug/L.|Method: USGS-NWQL O-4433-06; Procedure: continuous liquid-liquid extractor with gas chromatography with mass spectrometry detection; Analyte: tri(2-butoxyethyl) phosphate; Matrix: whole wastewater and environmental water samples; Detection Limit: 0.05 ug/L.|TBEP is usually analysed by gas chromatography (GC) coupled with mass spectrometry (MS), infrared spectroscopy or nuclear magnetic resonance spectrometry|Method: NIOSH 7905, Issue 2; Procedure: gas chromatography, phosphorus flame photometric detection; Analyte: phosphorus; Matrix: air; Detection Limit: 0.005 ug/sample. /Phosphorus/

Plasticizer tributoxyethyl phosphate was identified in post-mortem blood sample. Presence of plasticizers in blood samples can arise by contamination from rubber stopper of blood specimen containers.|A method of analysis was developed for the determination of organic phosphate triesters in human adipose tissues at low ng/g levels. After fat extraction from the tissue with benzene (or Me2CO-hexane, 15 + 85), phosphates were fractioned from fat by gel permeation chromatography with CH2Cl2-cyclohexane (5 + 95) as solvent. After Florisil column cleanup, the gel permeation chromatography extract was analyzed by capillary column gas chromatography using a N-P selective detector. Recoveries at the 2.5, 10, and 25 ng/g levels were >75% except for tri(2,4-xylenyl) phosphate (approx 65%). Of 16 human adipose tissue samples analyzed, 5 contained tris(1,3-dichloroisopropyl) phosphate in the range 0.5-110 ng/g, 4 contained tributoxyethyl phosphate in the range 4.0-26.8 ng/g, and 1 contained tributyl phosphate at 9.0 ng/g.|An analytical method for the determination of 14 organophosphorus flame retardants (OPFRs), including halogenated OPFRs, non-halogenated OPFRs and triphenyl phosphine oxide (TPPO) in biological samples was developed using gas chromatography-mass spectrometry (GC/MS). Biological samples were extracted using microwave-assisted extraction (MAE) with hexane/acetone (1:1, v/v) as the solvent; then, a two-step clean-up technique, gel permeation chromatography (GPC) combined with solid phase extraction (SPE), was carried out before GC/MS analysis. Experimental results showed that the developed method efficiently removed the lipid compounds and co-extract interferences. Moreover, using the relatively "narrow" column (with an i.d. of 10 mm) significantly decreased the elution volume and, therefore, prevented the loss of the most volatile OPFRs, especially trimethyl phosphate (TMP) and triethyl phosphate (TEP). The method detection limits (MDLs) for OPFRs in the biological samples ranged from 0.006 to 0.021 ng g(-1) lw, and the recoveries were in the range of 70.3-111%, except for TMP (38.9-55.6%), with relative standard deviations (RSDs) of less than 14.1%. The developed method was applied to determine the amount of the target OPFRs in biological samples (i.e., fish and domestic birds) that were collected from the Pearl River Delta (PRD) region in southern China. Of the 14 OPFRs, tri-n-butyl phosphate (TnBP), tris(2-chloroethyl) phosphate (TCEP), tris(chloropropyl) phosphate (TCPP) and tributoxyethyl phosphate (TBEP) were present in all of the biological samples that were analyzed, and dominated by TnBP, TCEP and TBEP. The concentrations of OPFRs in the biological samples that were collected from the PRD region were higher than those reported in other locations.

EPA Safer Chemical Functional Use Classes -> Specialized Industrial Chemicals|Safer Chemical Classes -> Yellow triangle - The chemical has met Safer Choice Criteria for its functional ingredient-class, but has some hazard profile issues