N-Methylacetamide

73.09

73.09

1071255

201-182-6

V0T777481M

747

DTXSID0047167

NEEDLES

29241900

29.1

-1.1

colourless liquid or solid

0.9371 g/cm³ @ Temp: 25 °C

28 °C

205 °C

227 °F

1.410

H2O: soluble

Store below +30°C.

0.44 mm Hg at 23 deg C.

Oral-Rat LD50: 5000 mg/kg

Flammable; burning produces toxic nitrogen oxide gas

3.2-18.1%(V)

5.20e-12 cm3/molecule*sec

pK(BH+; protonated base)= 1.25 @ 25 °C

Hydroxyl radical rate constant = 5.20X10-12 cu cm/molecule sec @ 25 °C

59.4 kJ/mol

Critical temperature: 417 °C

Ⅲ

2811

2

61

53-45

AC5960000

T

Warehouse ventilated, low temperature and dry

Stable. Combustible. Incompatible with strong oxidizing agents.

P201-P308 + P313

H360D

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

|Danger|H360D ***: May damage the unborn child [Danger Reproductive toxicity]|P201, P202, P281, P308+P313, P405, and P501|H360 (100%): May damage fertility or the unborn child [Danger Reproductive toxicity]|Aggregated GHS information provided by 140 companies from 7 notifications to the ECHA C&L Inventory.|H360D: May damage the unborn child [Danger Reproductive toxicity]|Warning|H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

moderately toxic

SIMULTANEOUS TREATMENT OF PREGNANT RATS WITH SODIUM NITRITE IN DRINKING WATER & N-METHYLACETAMIDE PRODUCED GREATER TERATOGENIC EFFECTS THAN TREATMENT WITH N-METHYLACETAMIDE ALONE. THUS, ENDOGENOUS NITRATION OF CMPD MAY BE TERATOGENIC FACTOR.

LD50 Rat ip, subcutaneous or oral administration 5-7 g/kg|LD50 Mouse ip 6.1 g/kg|LD50 Rat oral 5 g/kg|LD50 Rat ip 2750 mg/kg|For more Non-Human Toxicity Values (Complete) data for N-METHYLACETAMIDE (7 total), please visit the HSDB record page.

N-Methylacetamide's production and use as a solvent(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 6(SRC), determined from a log Kow of -1.05(2) and a regression-derived equation(3), indicates that N-methylacetamide is expected to have very high mobility in soil(SRC). Volatilization of N-methylacetamide from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.23X10-8 atm-cu m/mole(SRC), derived from its vapor pressure, 0.44 mm Hg(4), and water solubility, 1.0X10+6 mg/l(5). N-Methylacetamide is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.44 mm Hg(4). N-Methylacetamide (at 100 ppm), exposed to an activated sludge inoculum for two weeks under aerobic conditions, was categorized as biodegradable(6) and is expected to biodegrade in soil(SRC).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 6(SRC), determined from an measured log Kow of -1.05(2) and a regression-derived equation(3), indicates that N-methylacetamide is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 4.23X10-8 atm-cu m/mole(SRC), derived from its vapor pressure, 0.44 mm Hg(4), and water solubility, 1.0X10+6 mg/l(5). According to a classification scheme(6), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). N-Methylacetamide (at 100 ppm), exposed to an activated sludge inoculum for two weeks under aerobic conditions, was categorized as biodegradable(8), and is expected to biodegrade in water(SRC). N-Methylacetamide (at 50 ppm carbon), under anaerobic conditions, was not biodegraded over a 4 week period using a 10% activated sludge inoculum(9).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), N-methylacetamide, which has a vapor pressure of 0.44 mm Hg at 23 °C(2), is expected to exist solely as a vapor in the ambient atmosphere(SRC). Vapor-phase N-methylacetamide is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 3.1 days(SRC), calculated from its rate constant of 5.2X10-12 cu cm/molecule-sec at 25 °C(3).

The rate constant for the vapor-phase reaction of N-methylacetamide with photochemically-produced hydroxyl radicals is 5.20X10-12 cu cm/molecule-sec at 27 °C(1). This corresponds to an atmospheric half-life of about 3.1 days(SRC) at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(2). N-Methylacetamide is not expected to undergo hydrolysis in the environment due to the slow rate of reaction for amide functional groups nor to directly photolyze due to the lack of absorption in the environmental UV spectrum (>290 nm)(SRC).

An estimated BCF of 2 was calculated for N-methylacetamide(SRC), using a log Kow of -1.05(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of N-methylacetamide is estimated as 6(SRC), using a log Kow of -1.05(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that N-methylacetamide is expected to have very high mobility in soil(SRC).

The Henry's Law constant for N-methylacetamide is estimated as 4.23X10-8 atm-cu m/mole(SRC) based upon its vapor pressure, 0.44 mm Hg(1), and water solubility, 1.0X10+6 mg/l(2). This Henry's Law constant indicates that N-methylacetamide is expected to be essentially nonvolatile from water surfaces(3). N-Methylacetamide is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.44 mm Hg(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 851 workers (187 of these are female) are potentially exposed to N-methylacetamide in the US(1). Occupational exposure to N-methylacetamide may occur through inhalation and dermal contact with this compound at workplaces where N-methylacetamide is produced or used(SRC).

The determination of urinary N-monomethylacetamide (MMAC) in the end of shift urine sample was used to /evaluate/ worker exposure to dimethylacetamide (DMAC). Five workers were observed and followed for 4 consecutive weeks. Airborne DMAC appeared to account for the greatest amount of urinary MMAC detected, and at the exposure concn encountered ().5 to 2 ppm), a relationship of 10 ppm urinary MMAC for each 1 ppm DMAC inhaled was observed. ... It was concluded that changes in DMAC exposures can be quantitatively reflected by urinary MMAC.

MONOMETHYLACETAMIDE IS A METABOLITE OF DIMETHYLACETAMIDE & APPEARS IN MEASURABLE AMOUNTS IN URINE AFTER SINGLE EXPOSURE TO A TLV (THRESHOLD LIMIT VALUE) DOSE OF DIMETHYLACETAMIDE.|In a recent comparative toxicity & metab study of 4 formamides & on N-methylacetamide, the sole metabolite of N-methylacetamide in the urine of mice was identified as N-(hydroxymethyl)acetamide. There was no evidence of induction of hepatic drug metabolizing enzymes in rats following treatment with N-methylacetamide. N-Methylacetamide influenced neither the sleeping time induced by hexobarbital nor the metabolism of hexobarbital or aniline.

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/

/Liver toxicity was assessed in/ workers /exposed/ to N,N-dimethylacetamide (DMAC) in an acrylic fiber manufacturing facility. /Measurements were made/ over a 1 yr study period. ... Evidence of liver toxicity was assessed by serum clinical chemistry tests (serum levels of total bilirubin, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, & gamma-glutamyl transpeptidase) at least once during the study period for all 127 male workers in the two study departments & for 217 male in plant controls with no previous or current exposure to DMAC. If a worker's biomonitoring results exceeded one of two trigger values established for the study (60 mg N-methylacetamide/g creatinine or 136 mg DMAC equivalent/g creatinine), addnl serum clinical chemistry tests were conducted at weekly intervals for 3 wk. DMAC exposed workers were classified as either high exposure, if 1 or more biomonitoring result exceeded one of the trigger values, or unspecified exposure if none of them did. Control group employees were classified as no exposure. Mean DMAC in air levels for the high & unspecified exposure groups appeared to differ (geometric mean DMAC in air levels of 1.9 & 1.3 ppm 12 hr time weighted avg, respectively). No significant DMAC exposure related trends in hepatic serum clinical chemistry results were detected. Neither transient incr in serum analyte levels after a high biomonitoring result (one that exceeded a trigger value) nor an elevated mean level over the study period when compared with in plant controls were observed. These results /indicate/ that brief threshold limit value level exposures & chronic low level exposure (maximum likelihood estimate of the arithmetic mean for DMAC in air for the high exposure group over the study period was 3.0 ppm 12 hr time weighted avg) do not cause hepatotoxic clinical chemistry responses. /N,N-dimethylacetamide/

N-methyl acetamide

USEPA/OPP Pesticide Code 067301; Trade Names: Coop turbex; Turbex, Onyxide.

Acetamide, N-methyl-: ACTIVE|DIMETHYL SULFOXIDE, N-METHYL ACETAMIDE & PYRIDINE N-OXIDE WERE MOST EFFECTIVE AGENTS TESTED FOR INDUCING DIFFERENTIATION OF MURINE ERYTHROLEUKEMIA CELLS IN VITRO.

N-METHYL-ACETAMIDE WHEN PRESENT IN URINE IN CONCN BETWEEN 5-500 UL/L CAN BE MEASURED BY DIRECT INJECTION OF AN ALIQUOT OF A SPECIMEN ON A CHROMOSORB 103 COLUMN OF A GAS CHROMATOGRAPH.