Dioxone

171.196

171.19

211-867-1

Z0SPD4Z01X

169418

DTXSID0061032

CRYSTALS FROM ETHER

55.4

1.38800

1.069g/cm3

97-98 °C

1.44

LD50 in mice, rats (mg/kg): 52, 31.6 i.p.; 130, 70.5 orally (Maffii)

EFFECTS OF ANTIEPILEPTIC DRUGS ADMINISTERED 1-4 DAYS BEFORE ON CONVULSANT EFFECTS OF DIOXONE WERE STUDIED IN MICE. METHYLPHENOBARBITAL, PRIMIDONE & METHOIN ENHANCED THE EFFECT WHEN GIVEN 2 DAYS PRIOR TO DIOXONE ADMINISTRATION. SODIUM PHENYTOIN HAD AN ANTICONVULSANT EFFECT IN THE FIRST 2 DAYS & AFTER 4 DAYS THE DOSAGE OF DIOXONE NECESSARY TO INDUCE CONVULSIONS IN 50 OF THE ANIMALS WAS DIMINISHED.|THE HYPNOTICS, PENTOBARBITONE SODIUM & HYDROXYDIONE WERE TITRATED BY DIETHADIONE USING HYPNOSIS IN 50 MICE AS THE TITRATION END-POINT. ANTAGONISM OF HYPNOSIS BY DIETHADIONE MAY BE COMPETITIVE OR NONCOMPETITIVE.|THE QUANTITY OF HYPNOTIC, AMYLOBARBITONE SODIUM, REQUIRED TO MAINTAIN THE TITRATION END-POINT HYPNOSIS IN 50 MICE IN PRESENCE OF INCREASING DOSES OF ANALEPTICS SUCH AS BEMEGRIDE, DIETHADIONE, PICROTOXIN, PENTYLENETETRAZOLE, & BETA-SPIROCYCLOPENTANEGLUTARIMIDE WAS STUDIED. WITH THE EXCEPTION OF PICROTOXIN, TITRATION CURVES SHOWED A REVERSAL IN SLOPE AT THE HIGHEST DOSES, & DIETHADIONE ENHANCED THE DEPRESSANT ACTION OF THE HYPNOTIC. THESE ANALEPTICS & THE HYPNOTIC PROBABLY ALL ACT AT THE SAME EXCITATORY SYNAPSES, THE FORMER AS AGONISTS & THE LATTER AS COMPETITIVE OR NONCOMPETITIVE ANTAGONIST.

IN RAT & RABBIT SERUM DIOXONE WAS BOUND MAINLY BY GLOBULINS & A SMALL EXTENT ALSO BY ALBUMINS.

2H-1,3-Oxazine-2,4(3H)-dione, 5,5-diethyldihydro-: INACTIVE