4-BROMO-BENZOTHIAZOL-5-YLAMINE
-
4-BROMO-BENZOTHIAZOL-5-YLAMINE
structure -
-
CAS No:
769-19-7
-
Formula:
C7H5BrN2S
-
Chemical Name:
4-BROMO-BENZOTHIAZOL-5-YLAMINE
-
Synonyms:
5-Benzothiazolamine, 4-bromo-;5-AMINO-4-BROMO-BENZOTHIAZOLE;4-BROMO-BENZOTHIAZOL-5-YLAMINE;4-BroMobenzo[d]thiazol-5-aMine;4-broMo-1,3-benzothiazol-5-aMine;5-Amino-4-bromo-1,3-benzothiazole;4-Bromo-1,3-benzothiazol-5-ylamine
-
CAS No:
Safety Information
45
T
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
4-BROMO-BENZOTHIAZOL-5-YLAMINE Use and Manufacturing
A solution of Br2 (2.3 g, 14.4 mmol) in CHC13 (10 mL) was added dropwise to a solution of benzo[d]thiazol-5-amine (2.1 g, 14.0 mmol) in CHC13 (100 mL) at 10 °C. The mixture was stirred at room temperature for 1 hour. The reaction mixture was basified with saturated aqueous Na2CO3 (100 mL) and extracted with DCM (3x30 mL). The combined organic layers were dried over Na2SO4 and concentrated in vacuo. The residue was purified by column chromatography on silica gel (EtOAc/petroleum ether = 1 :81 :4) to afford the title compound as yellow solids (2.3 g). 1H NMR (300 MHz, CDCl3): ö 9.01 (s, 1H), 7.66 (d, 1H), 6.95 (d, 1H), 4.33 (s, 2H).