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Chloroxine

Chloroxine structure

CAS No:
773-76-2
Formula:
C9H5Cl2NO
Chemical Name:
Chloroxine
Synonyms:
8-Quinolinol,5,7-dichloro-;5,7-Dichloro-8-quinolinol;CHQ;5,7-Dichloro-8-hydroxyquinoline;5,7-Dichloroxine;5,7-Dichloro-8-oxyquinoline;Dichlorohydroxyquinoline;Chloroxine;Quesyl;Clofuzid;Dichloroxin;Chloroxyquinoline;Endiaron;Dichloroquinolinol;Quixalin;Quinolor;5,7-Dichlorooxine;Chlofucid;Capitrol;NSC 3904
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

Chloroxine is a synthetic antibacterial compound that is effective in the treatment of dandruff and seborrheic dermatitis when incorporated in a shampoo.Target: AntibacterialChloroxine is an antibacterial drug. Oral formulations are used in infectious diarrhea, disorders of the intestinal microflora (e.g. after antibiotic treatment), giardiasis, inflammatory bowel disease. It is also useful for dandruff and seborrheic dermatitis, as used in shampoos and dermal creams like. Chloroxine has

Solid

Chloroxine is a monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 have been substituted by chlorine. A synthetic antibacterial prepared by chlorination of quinolin-8-ol, it is used for the treatment of dandruff and seborrhoeic dermatitis of the scalp. It has a role as an antibacterial agent, an antiseborrheic and an antifungal drug. It is a monohydroxyquinoline and an organochlorine compound. It derives from a quinolin-8-ol.|Chloroxine is a synthetic antibacterial compound. Chloroxine is a compound used in some shampoos for the treatment of dandruff and seborrheic dermatitis of the scalp.|Chloroxine is a synthetic quinoline derivative with antibacterial activity. Although the mechanism of action is not fully understood, topical administration of chloroxine diminishes mitotic activity in the epidermis, thereby reducing excessive scaling associated with dandruff or seborrheic dermatitis of the scalp, including psoriasis and eczema.

Chloroxine Basic Attributes

Molecular Weight：

214.05

Exact Mass：

214.05

BRN：

153606

EC Number：

212-258-3

UNII：

2I8BD50I8B

NSC Number：

758398|3904

DSSTox ID：

DTXSID5022801

NCI Thesaurus Code：

C47446

HScode：

2933499090

Characteristics

PSA：

33.1

XLogP3：

3.5

Appearance：

Light beige Fluffy Powder

Density：

1.5±0.1 g/cm3

Melting Point：

179.5 °C

Boiling Point：

355ºC

Flash Point：

168.3±26.5 °C

Refractive Index：

1.702

Water Solubility：

1.38e-01 g/L

Storage Conditions：

2-8°C

Collision Cross Section：

134.3 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

22-37/38-41-36/37/38

safety instructions：

26-36-37/39-25-22

RTECS Number：

VC5350000

Marks：

Xn,Xi

Stability/Shelf Life：

Stable at room temperature in closed containers under normal storage and handling conditions.

Precautionary statement(s)：

P261-P280-P305 + P351 + P338

Hazard Statements：

H302-H315-H318-H335

GHS Classification：

|Danger|H302 (89.58%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 48 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity Summary：

The toxicological properties of this material have not been investigated.

Drug Information

Drug Indication：

Used in the treatment of dandruff and mild to moderately severe seborrheic dermatitis of the scalp.

Pharmacology：

Chloroxine has an antibacterial action, inhibiting the growth of gram-positive as well as some gram-negative organisms. Also, chloroxine has shown some antifungal activity against certain dermatophytes and yeasts.

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)|Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)

Mechanism of Action：

Although the mechanism of action is not understood, chloroxine may slow down mitotic activity in the epidermis, thereby reducing excessive scaling associated with dandruff or seborrheic dermatitis of the scalp. Chloroxine induces SOS-DNA repair in E. coli, so chloroxine may be genotoxic to bacteria.

MeSH Entry Terms：

chloroxine

Chloroxine Use and Manufacturing

Uses

Analytical reagent.

Manufacturing Info：

8-Quinolinol, 5,7-dichloro-: ACTIVE

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:214.04
XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:212.9748192
Monoisotopic Mass:212.9748192
Topological Polar Surface Area:33.1
Heavy Atom Count:13
Complexity:191
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Chloroxine

Xi'an Honest BioEngr Co.,Ltd. Contact Supplier

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High-purity raw material 5,7-Dichloro-8-hydroxyquinolin CAS 773-76-2 at competitive pricing

Unit Price: $66-77 /G FOB

CAS No.: 773-76-2

Grade: Pharmaceutical Grade

Content: 99%

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HONGKONG IPURE CHEMICAL CO., LIMITED Contact Supplier

HK
1 YR

Business licensed

Trader Supplier of pharmaceutical intermediates,chemical

5,7-Dichloro-8-hydroxyquinoline 773-76-2

Unit Price: $1-1.3 /MT FOB

CAS No.: 773-76-2

Grade: pharmaceutical grade

Content: 99%

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