3-CYANOPYRROLE

After methyl 1H-To a solution oft-butyl 5-bromopyrimidin-2-yl((trans-3-fluoro-l-(3-fluoropyridin- 2-yl)cyclobutyl)methyl) carbamate (1.0 g, 2.8 mmol) in 15 mL of toluene (degassed with nitrogen) was added copper iodide (100 mg, 0.6 mmol), potassium phosphate (1.31 g, 6.2 mmol), trans-N, N'-dimethylcyclohexane-l, 2-diamine (320 mg, 2.2 mmol), and 3- cyanopyrrole (310 mg, 3.6 mmol). The reaction was heated to 100 C and stirred for 2 h. The reaction was then concentrated and purified by silica gel chromatography (EtOAc/hexanes) to afford 1.1 g of t-butyl 5-(3-cyano-lH-pyrrol-l-yl)pyrimidin-2-yl(((trans)-3-fluoro-l-(3- fluoropyridin-2-yl)cyclobutyl)methyl)carbamate as a clear oil.(5)-3-(3-Cyano-lH-pyrrol-l-yl)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy^ (0697) methylpropanamide (C17H13 (0698) (0699) [00318] To a solution of lH-

Molecular Weight:92.10
XLogP3:0.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Exact Mass:92.037448136
Monoisotopic Mass:92.037448136
Topological Polar Surface Area:39.6
Heavy Atom Count:7
Complexity:99.9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes