Bephenium
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Bephenium
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CAS No:
7181-73-9
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Formula:
C17H22NO
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Chemical Name:
Bephenium
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Synonyms:
Benzenemethanaminium,N,N-dimethyl-N-(2-phenoxyethyl)-;Ammonium,benzyldimethyl(2-phenoxyethyl)-;N,N-Dimethyl-N-(2-phenoxyethyl)benzenemethanaminium;Bephenium
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CAS No:
Bephenium Basic Attributes
256.36268
256.17
230-546-7
PXO9B4983I
DTXSID3022661
P - Antiparasitic products, insecticides and repellents
Characteristics
9.2
3.4
MP: 170-171 °C /HYDROXYNAPHTHOATE/|MP: 144-146 °C /PAMOATE SALT/|MP: 135-136 °C /CHLORIDE SALT/|MP: 144.5-146 °C /BROMIDE SALT/|MP: 146-147 °C /IODIDE SALT/
162.3 Ų [M]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
ODORLESS; BITTER TASTE /HYDROXYNAPHTHOATE SALT/|CRYSTALS /HYDROXYNAPHTHOATE SALT/|PALE YELLOW SOLID FROM WATER /PAMOATE DIHYDRATE/|CRYSTALS FROM ACETONE /CHLORIDE SALT/|For more Other Experimental Properties (Complete) data for BEPHENIUM (7 total), please visit the HSDB record page.
Drug Information
BEPHENIUM HYDROXYNAPHTHOATE IS HIGHLY EFFECTIVE, WHEN GIVEN IN SINGLE DOSE, AGAINST BOTH SPECIES OF HUMAN HOOKWORMS & AGAINST...INFESTATIONS WITH ASCARIS LUMBRICOIDES & TRICHOSTRONGYLUS ORIENTALIS. ...INEFFECTIVE AGAINST STRONGYLOIDES STERCORALIS & HAS...MODERATE ACTIVITY AGAINST TRICHURIS TRICHIURA. /HYDROXYNAPHTHOATE/|BEPHENIUM HYDROXYNAPHTHOATE IS GIVEN ORALLY ON EMPTY STOMACH, & FOOD IS THEN WITHHELD FOR @ LEAST 2 HR. ... /HYDROXYNAPHTHOATE/|MEDICATION (VET): ANTHELMINTIC. /USED/...TO CONTROL & TREAT NEMATODIRUS, OSTERTAGIA, COOPERIA, HEMONCHUS, & TRICHOSTRONGYLUS INFESTATIONS IN CATTLE & SHEEP. /EMBONATE & HYDROXYNAPHTHOATE SALTS/|MEDICATION (VET): ...WIDELY USED FOR PREVENTION & TREATMENT OF NEMATODIRIASIS IN LAMBS... /HYDROXYNAPHTHOATE SALT/ BEPHENIUM EMBONATE IS USED FOR SIMILAR PURPOSES. /EMBONATE SALT/|MEDICATION (VET): TO CONTROL & TREAT...HOOKWORMS IN CATS & DOGS. /HYDROXYNAPHTHOATE SALT/
DEHYDRATION, ELECTROLYTE IMBALANCE, & DIARRHEA SHOULD BE CORRECTED BEFORE DRUG IS USED. INFORMATION IS LACKING ON SAFETY OF BEPHENIUM DURING PREGNANCY; THEREFORE, POSSIBLE RISK TO FETUS SHOULD BE WEIGHED AGAINST EXPECTED THERAPEUTIC BENEFITS IF THIS AGENT IS CONSIDERED FOR USE IN PREGNANT WOMEN. /HYDROXYNAPHTHOATE SALT/|SIDE EFFECTS ARE USUALLY MINIMAL... DRUG SHOULD BE USED WITH CAUTION IN HYPERTENSIVE PT & OTHERS WITH LABILE BLOOD PRESSURE; IT HAS MILD GANGLIONIC BLOCKING ACTION & IF ABSORBED MIGHT CAUSE BRIEF MARKED FALL IN BLOOD PRESSURE. /HYDROXYNAPHTHOATE SALT/|SPECIAL CAUTION IS INDICATED IF ANTHELMINTICS ARE USED IN PT WITH SEVERE HEPATIC, RENAL, OR CARDIAC DISEASE.../&/ IN CHILDREN UNDER 1 YR OF AGE. /ANTHELMINTICS/
AFTER ORAL ADMIN OF THERAPEUTIC DOSE OF BEPHENIUM HYDROXYNAPHTHOATE NOT MORE THAN 0.5% IS EXCRETED IN URINE WITHIN 24 HR. /HYDROXYNAPHTHOATE/|NOT ORDINARILY ABSORBED FROM GI TRACT, BUT IF INTESTINES ARE INFLAMED, SOME DRUG MAY BE ABSORBED...EXCRETED IN URINE. /HUMAN, ORAL/
BECAUSE OF ITS BITTER TASTE, DRUG MAY PROVOKE NAUSEA & VOMITING... OCCASIONALLY IT MAY CAUSE MILD & TEMPORARY LOOSENESS OF STOOL. /HYDROXYNAPHTHOATE SALT; ORAL ADMIN/
Bephenium Use and Manufacturing
It is derived from phenol through condensation, amination, formation of quaternary ammonium salt, and replacement.
This product is a broad-spectrum anti-enteric drug, which is effective against hookworm, roundworm and whipworm disease. The anti-hookworm effect is the best and the curative effect is better than that of tetrachloroethylene and bromonaphthol. The rate of deworming was 87.8% within three days after taking the medicine. However, these quaternary ammonium compounds are poorly absorbed in the intestine, with low oral toxicity, and clinical reactions are mostly gastrointestinal irritation symptoms, such as nausea, vomiting, abdominal pain, and diarrhea. The adverse reactions of quaternary ammonium drugs are more and serious, and they have been gradually used less or not. For example, benzphenoxide has been used to treat hookworm infections, and has been replaced by mebendazole and thiuracil. Michongning tablet is one of the 127 eliminated drugs announced by the Ministry of Health in 1982.
BEPHENIUM HYDROXYNAPHTHOATE, USP (ALCOPARA), IS AVAILABLE IN OFFICIAL SINGLE-DOSE SACHETS OF 5 G, CONTAINING EQUIVALENT OF 2.5 G OF BEPHENIUM BASE.
Computed Properties
Molecular Weight:256.36
XLogP3:3.4
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:6
Exact Mass:256.170139325
Monoisotopic Mass:256.170139325
Topological Polar Surface Area:9.2
Heavy Atom Count:19
Formal Charge:1
Complexity:240
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes