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Pseudoephedrine sulfate

Pseudoephedrine sulfate structure

CAS No:
7460-12-0
Formula:
C10H15NO.¹/2H2O4S
Chemical Name:
Pseudoephedrine sulfate
Synonyms:
Benzenemethanol,α-[(1S)-1-(methylamino)ethyl]-,(αS)-,sulfate (2:1);Pseudoephedrine,sulfate (2:1),(+)-;Benzenemethanol,α-[1-(methylamino)ethyl]-,[S-(R*,R*)]-,sulfate (2:1) (salt);Benzenemethanol,α-[(1S)-1-(methylamino)ethyl]-,(αS)-,sulfate (2:1) (salt);(+)-Isoephedrine sulfate;d-Isoephedrine sulfate;threo-1-Hydroxy-2-methylamino-1-phenylpropane sulfate;Pseudoephedrine sulfate;Afrinol;Afrin Tablets;d-Pseudoephedrine sulfate;Duration Tablets;Drixoral ND;Sch 4855;Chlor-Trimeton ND;93778-69-9
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Pseudoephedrine Sulfate is the sulfate salt form of pseudoephedrine, a phenethylamine and a diastereomer of ephedrine with sympathomimetic property. Pseudoephedrine sulfate displaces norepinephrine from storage vesicles in presynaptic neurones, thereby releasing norepinephrine into the neuronal synapses where it stimulates primarily alpha-adrenergic receptors. It also has weak direct agonist activity at alpha- and beta- adrenergic receptors. Receptor stimulation results in vasoconstriction and decreases nasal and sinus congestion.

Pseudoephedrine sulfate Basic Attributes

Molecular Weight：

428.54300

Exact Mass：

428.19800

EC Number：

231-243-2

UNII：

Y9DL7QPE6B

NCI Thesaurus Code：

C47696

HScode：

29394200

Characteristics

PSA：

147.50000

XLogP3：

3.86560

Melting Point：

175-179°C (lit.)

Boiling Point：

255ºC at 760 mmHg

Flash Point：

85.6ºC

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

UN 1544

Precautionary statement(s)：

P301 + P312 + P330-P305 + P351 + P338

Hazard Statements：

H302-H315-H319-H335

GHS Classification：

|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P260, P261, P264, P270, P271, P272, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P314, P321, P330, P332+P313, P333+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 162 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Pseudoephedrine sulfate Use and Manufacturing

Uses

Decongestant.

Manufacturing Info：

Benzenemethanol, .alpha.-[(1S)-1-(methylamino)ethyl]-, (.alpha.S)-, sulfate (2:1): ACTIVE

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:428.5
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:6
Exact Mass:428.19810792
Monoisotopic Mass:428.19810792
Topological Polar Surface Area:148
Heavy Atom Count:29
Complexity:202
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes