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Monoethylglycinexylidide

Monoethylglycinexylidide structure

CAS No:
7728-40-7
Formula:
C12H18N2O
Chemical Name:
Monoethylglycinexylidide
Synonyms:
Acetamide,N-(2,6-dimethylphenyl)-2-(ethylamino)-;2′,6′-Acetoxylidide,2-(ethylamino)-;N-(2,6-Dimethylphenyl)-2-(ethylamino)acetamide;L 86;N-Ethylglycinexylidide;Monoethylglycinexylidide;2-(Ethylamino)-2′,6′-acetoxylidide;ω-Ethylamino-2′,6′-dimethylacetanilide;Monoethylglycylxylidide;Norlidocaine;MEGX;N-(N-Ethylglycyl)-2,6-xylidine;126912-02-5
Categories:
Organic Chemistry > Amides

Description

White Solid

Monoethylglycinexylidide is amino acid amide formed from 2,6-dimethylaniline and N-ethylglycine components; an active metabolite of lidocaine, formed by oxidative deethylation. Used as an indicator of hepatic function. It has a role as a drug metabolite.

Monoethylglycinexylidide Basic Attributes

Molecular Weight：

206.28400

Exact Mass：

206.28

UNII：

D8Q99HC770

DSSTox ID：

DTXSID60228006

HScode：

2924299090

Characteristics

PSA：

41.13000

XLogP3：

2.31530

Density：

1.047g/cm3

Melting Point：

47-49 °C

Boiling Point：

164-165 °C @ Press: 1.3 Torr

Flash Point：

127.8ºC

Refractive Index：

1.553

Water Solubility：

25.2 [ug/mL]

Storage Conditions：

-20ºC Freezer

Safety Information

Transport codes：

UN 2811 6.1 / PGIII

wgk germany：

safety instructions：

RTECS Number：

AN7740000

Marks：

Precautionary statement(s)：

P301 + P310

Hazard Statements：

H301

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

Drug Transformations：

Norlidocaine is a known transformation product of Lidocaine.

Metabolism/Metabolites：

Monoethylglycinexylidide has known human metabolites that include 3-Hydroxymonoethyl glycinexylidide and Glycinexylidide.

MeSH Entry Terms：

ethylglycylxylidide

Monoethylglycinexylidide Use and Manufacturing

Uses

A metabolite of Lidocaine (L397800).

Use Classification：

Pharmaceuticals -> Transformation products

Computed Properties

Molecular Weight:206.28
XLogP3:1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:206.141913202
Monoisotopic Mass:206.141913202
Topological Polar Surface Area:41.1
Heavy Atom Count:15
Complexity:196
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 7728-40-7

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