Cupric chloride

134.45

132.867310

231-210-2

165706

2802

DTXSID7040449

Yellow to brown, microcrystalline powder|Yellow-brown, monoclinic crystals

28274990

0

-5.99450

Yellow-brown powder

3.39 g/cm³ @ Temp: 25 °C

231 °C

993°C/760mmHg

H2O: 620 g/L (20 ºC)

2-8°C

Oral-Rat  LD50: 584  mg/kg; Oral-Mouse LD50: 233 mg/kg

Non-combustible; Fire produces toxic copper and chloride fumes;

Deliquescent. ... Partially decomp above 300 °C to CUCl + Cl2. ... mp of 498 °C usually reported for this compd is the metling pt of a mixture of CuCl2 and CuCl. ... Forms dihydrate in moist air.|Heat of fusion: 4890 cal/g mole, 24.7 cal/g|Density: 2.54; solubility: 76 parts/100 parts water @ 25 °C /Dihydrate/|Odorless; in the presence of moisture may corrode metals

The anhydrous form is hygroscopic, forming the dihydrate. The dihydrate is deliquescent in moist air, efflorescent in dry air. Both are water soluble. May corrode metals in the presence of moisture; the reaction is not hazardous (USCG, 1999).

Salts, Acidic

Solutions of COPPER CHLORIDE are acidic (they contain moderate concentrations of hydrogen ions and have pH's of less than 7.0). They react as acids to neutralize bases. These neutralizations generate heat, but far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid.

It is corrosive to aluminum.

III

8

UN 3264 8/PG 3

2

52/53-50/53-36/37/38-25-22-51/53-41-23/24/25-50-36-21/22-38

61-57-45-37/39-29-26-60-36-44-36/37/39-28-39

GL7000000

N,T,Xn,Xi

Treasury is low temperature, ventilated, dry; stored separately from food raw materials

Stable. Reacts violently with potassium and sodium. Contact with acetylene may form explosive acetylides. Hygroscopic.

P273-P280-P305 + P351 + P338

H302 + H312-H315-H318-H410

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

... ON CONTACT WITH ACIDS OR ACID FUMES THEY EVOLVE HIGHLY TOXIC /HYDROGEN CHLORIDE/ FUMES. /CHLORIDES/|MIXTURE OF POTASSIUM & ANY OF FOLLOWING METALLIC HALIDES PRODUCES STRONG EXPLOSION ON IMPACT: ... CUPRIC CHLORIDE. ...|MIXTURE OF SODIUM & ANY OF FOLLOWING METALLIC HALIDES PRODUCES STRONG EXPLOSION ON IMPACT: ... CUPRIC CHLORIDE. ...|Solutions of sodium hypobromite are decomposed by powerful catalytic action of cupric ions, even as impurities. /Cupric salts/

Special Hazards of Combustion Products: Irritating hydrogen chloride gas may form in fire. (USCG, 1999)

|Danger|H301 (16.81%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P273, P280, P301+P310, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 481 companies from 28 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H301 (86.21%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P273, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 29 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H301: Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P261, P264, P270, P272, P280, P281, P301+P310, P302+P352, P305+P351+P338, P308+P313, P321, P330, P332+P313, P333+P313, P337+P313, P362, P363, P405, and P501

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2016)

Bu. Mines approved respirator; rubber gloves; safety goggles (USCG, 1999)|Bureau of Mines approved respirator; rubber gloves; safety goggles.

It is noncombustible.

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.)

Environmental consideration - land spill: Dig a pit, pond, lagoon, or holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water.|Environmental consideration - water spill: Neutralize with agricultural lime (calcium oxide), crushed limestone (calcium carbonate), or sodium bicarbonate (NaHCO3). Use mechanical dredges or lifts to remove immobilized masses of pollutants & precipitates.

If material not involved in fire: Keep material out of water sources & sewers. Build dikes to contain flow as necessary.|Personnel protection: Keep upwind. ... Avoid breathing vapors or dusts. Wash away any material which may have contacted the body with copious amt of water or soap & water.|SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Health: TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.|/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Fire or Explosion: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.|/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas.|/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.|For more DOT Emergency Guidelines (Complete) data for COPPER(II) CHLORIDE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Contact with solutions irritates eyes; contact with solid causes ... eye surface injury. ...|IRRITATING TO SKIN, MUCOUS MEMBRANES.

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 1 mg/cu m. /Copper (dusts and mists)/

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 10 lb or 4.54 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

highly toxic

LD50 not available Copper toxicity can produce prostration, behavior change, diarrhea, progressive marasmus, hypotonia, photophobia and peripheral edema. Such symptoms have been reported with a serum copper level of 286 mcg/dl. Copper toxicity can also result in hemolysis and liver toxicity, including hepatic necrosis which may be fatal. D-penicillamine has been reported effective as an antidote.|For healthy, non-occupationally-exposed humans the major route of exposure to copper is oral. The mean daily dietary intake of copper in adults ranges between 0.9 and 2.2 mg. ... In some cases, drinking water may make a substantial additional contribution to the total daily intake of copper, particularly in households where corrosive waters have stood in copper pipes. ... All other intakes of copper (inhalation and dermal) are insignificant in comparison to the oral route. Inhalation adds 0.3-2.0 ug/day from dusts and smoke. Women using copper IUDs are exposed to only 80ug or less of copper per day from this source. The homeostasis of copper involves the dual essentiality and toxicity of the element. Its essentiality arises from its specific incorporation into a large number of proteins for catalytic and structural purposes. The cellular pathways of uptake, incorporation into protein and export of copper are conserved in mammals and modulated by the metal itself. Copper is mainly absorbed through the gastrointestinal tract. From 20 to 60% of the dietary copper is absorbed, with the rest being excreted through the feces. Once the metal passes through the basolateral membrane it is transported to the liver bound to serum albumin. The liver is the critical organ for copper homeostatis. The copper is partitioned for excretion through the bile or incorporation into intra- and extracellular proteins. The primary route of excretion is through the bile. The transport of copper to the peripheral tissues is accomplished through the plasma attached to serum albumin, ceruloplasmin or low-molecular weight complexes. ... The biochemical toxicity of copper, when it exceeds homeostatic control, is derived from its effects on the structure and function of biomolecules, such as DNA, membranes and proteins directly or through oxygen-radical mechanisms. The toxicity of a single oral dose of copper varies widely between species. ... The major soluble salts (copper(II) sulfate, copper(II) chloride) are generally more toxic than the less soluble salts (copper(II) hydroxide, copper (II) oxide). Death is preceded by gastric hemorrhage, tachycardia, hypotension, hemolytic crisis, convulsions and paralysis. ... Long-term exposure in rats and mice showed no overt signs of toxicity other than a dose-related reduction in growth after ingestion ... The effects included inflammation of the liver and degeneration of kidney tubule epithelium. ... Some testicular degeneration and reduced neonatal body and organ weights were seen in rats ... and fetotoxic effects and malformations were seen at high dose levels. ... Neurochemical changes have been reported after oral administration ... A limited number of immunotoxicity studies showed humoral and cell-mediated immune function impairment in mice after oral intakes in drinking-water ... Copper is an essential element and adverse health effects /in humans/ are related to deficiency as well as excess. Copper deficiency is associated with anemia, neutropenia and bone abnormalities but clinically evident deficiency is relatively infrequent in humans. .. Except for occasional acute incidents of copper poisoning, few effects are noted in normal /human/ populations. Effects of single exposure following suicidal or accidental oral exposure have been reported as metallic taste, epigastric pain, headache, nausea, dizziness, vomiting and diarrhea, tachycardia, respiratory difficulty, hemolytic anemia, hematuria, massive gastrointestinal bleeding, liver and kidney failure, and death. Gastrointestinal effects have also resulted from single and repeated ingestion of drinking-water containing high copper concentrations, and liver failure has been reported following chronic ingestion of copper. Dermal exposure has not been associated with systemic toxicity but copper may induce allergic responses in sensitive individuals. Metal fume fever from inhalation of high concentrations in the air in occupational settings have been reported ... A number of groups are described where apparent disorders in copper homeostasis result in greater sensitivity to copper deficit or excess than the general population. Some disorders have a well-defined genetic basis. These include Menkes disease, a generally fatal manifestation of copper deficiency; Wilson disease (hepatolenticular degeneration), a condition leading to progressive accumulation of copper; and hereditary aceruloplasminemia, with clinical symptoms of copper overload. Indian childhood cirrhosis and idiopathic copper toxicosis are conditions related to excess copper which may be associated with genetically based copper sensitivity ... These are fatal conditions in early childhood where copper accumulates in the liver. ... Other groups potentially sensitive to copper excess are hemodialysis patients and subjects with chronic liver disease. Groups at risk of copper deficiency include infants (particularly low birth weight/preterm babies, children recovering from malnutrition, and babies fed exclusively with cow's milk), people with maladsorption syndrome (e.g., celiac disease, sprue, cystic fibrosis), and patients on total parenteral nutrition. Copper deficiency has been implicated in the pathogenesis of cardiovascular disease. The adverse effects of copper must be balanced against its essentiality. Copper is an essential element for all biota ... At least 12 major proteins require copper as an integral part of their structure. It is essential for the utilization of iron in the formation of hemoglobin, and most crustaceans and molluscs possess the copper-containing hemocyanin as their main oxygen-carrying blood protein. ... A critical factor in assessing the hazard of copper is its bioavailablity. Adsorption of copper to particles and complexation by organic matter can greatly limit the degree to which copper will be accumulated ... At many sites, physiochemical factors limiting bioavailability will warrant higher copper limits. ...

The effects of superoxide dismutase, catalase, copper(II) (3,5-diisopropylsalicylate)2 and other copper compounds on radiation transformation in vitro using C3H 10T1/2 cells have been studied. When present only during irradiation, cupric chloride and cuprous chloride inhibited the initiation phase of radiation transformation.|The ameliorating effects of copper(+2) and sulfate(2-) ions on concurrent selenite toxicity were compared in two factorial experiments in weanling rats. 0, 500 and 1,000 mg copper (as cupric chloride)/kg diet were fed in conjuction with 0, 5, 10 and 20 mg selenium (as Na2Se)3)/kg diet. Cupric(+2) ion, but not sulfate(2-) ion, prevented mortality among selenite intoxicated rats. There were significant copper-selenium interaction effects on feed intake, daily gain, packed cell volume, serum copper and iron, sperm counts, and weights of liver, kidney and testis. Sulfate increased liver copper concentrations.|Oral LD50 values (at 24 and 168 hr) for 8 metal salts were detected in female mice pretreated orally with small doses (1/10 of the challenge doses) of the same metal ions or with deionized water at 24 hr prior to the challenge doses. Pretreatment with copper(2+), had little effect on the lethality of the same ion. Pretreatment with copper(2+), mercury(2+), or zinc(2+) protected mice against the toxic action of cadmium(2+).|Salts of metals which are carcinogenic, noncarcinogenic, or of unknown carcinogenicity were assayed for their abilities to modulate ultraviolet induced mutagenesis in Escherichia coli WP2. Copper chloride acted as comutagen in E coli WP2, which has wild type DNA repair capability, but was much less comutagenic in the repair deficient strain WP2S (uvra). The survival of irradiated or unirradiated cells was not affected by the compound. The comutagenic effects might occur either via metal induced decreases in the fidelity of repair replication or via metal induced depurination.|For more Interactions (Complete) data for COPPER(II) CHLORIDE (6 total), please visit the HSDB record page.

LD50 Rat Oral 140 mg/kg body weight LD50 Mouse Oral 190 mg/kg body weight LD50 Guinea pig Oral 32 mg/kg body weight /from table/

For use as a supplement to intravenous solutions given for total parenteral nutrition (TPN).

Copper is an essential nutrient which serves as a co factor for serum ceruloplasmin, an oxidase necessary for proper formation of the iron carrier protein, transferrin. Copper also helps maintain normal rates of red and white blood cell formation. Providing copper during Total Parenteral Nutrition helps prevent development of the following deficiency symptoms: Leukopenia, neutropenia, anemia, depressed ceruloplasmin levels, impaired transferrin formation, secondary iron deficiency and osteoporosis.

Mean copper absorption of 57 percent (range 40 to 70 per cent) following oral administration of 0.4 - 4.5 mg copper (as copper acetate) to four volunteers. An early human study suggested a maximum blood copper concentration was reached some two hours after oral copper chloride administration (1.5 - 12 mg copper)|Renal|Copper is distributed to all tissues with the highest concentrations in liver, heart, brain, kidneys and muscle. Intracellular copper is predominantly metallothionein-bound. Reported copper in the lungs, liver, kidney, blood, bile and stomach (33.7, 35.1, 41.4, 13.8, 2.8, and 2988 µg/g wet weight respectively)|ICR male mice aged 5 weeks were injected subcutaneously with cadmium chloride, lead acetate, silver nitrate, cupric chloride, a combination of cadmium and silver compounds, or a combination of copper and silver compounds. These injections were carried out 3 times. Twenty four hours after the last injection, they were sacrificed. Cadmium injection significantly stimulated serum ceruloplasmin activity and copper concentration, accompanied by an increase in hepatic copper. Lead injection also slightly increased the serum ceruloplasmin level. In contrast, silver injection markedly decreased both serum ceruloplasmin activity and copper concentration in the serum. Hepatic copper increased slightly after silver injection. The copper injection stimulated copper binding to metallothionein and bile excretion of copper, but not serum ceruloplasmin release. With a copper and silver combination, the effect of silver on serum ceruloplasmin was lost, with a concomitant disappearance of silver from the serum ceruloplasmin fraction in the serum. In the mouse, cadmium and silver, copper antagonistic metals, influence different sites of serum ceruloplasmin metabolism. Excess hepatic copper is partly eliminated by excretion of bile and is partly detoxified by metallothionein induction.

The in vitro interaction of organic copper compounds with rat liver glutathione S-transferases was studied with reduced glutathione and 1-chloro-2,4-dinitrobenzene as substrates. Both organic and inorganic copper are spontaneously conjugated with glutathione, but interact with glutathione S-transferase by direct binding to these proteins.

Inhalation causes coughing and sneezing. Ingestion causes pain and vomiting. Contact with solutions irritates eyes; contact with solid causes severe eye surface injury and skin irritation. (USCG, 1999)|Corrosives

INHALATION: move to fresh air. INGESTION: give large amounts of water; induce vomiting; get medical attention. EYES: flush with water for 15 min.; consult a doctor if injury was caused by solid. SKIN: flush with water. (USCG, 1999)

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Copper and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Start an IV with lactated Ringer's /SRP: "To keep open", minimal flow rate/. Watch for signs of fluid overload. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine, hydrochloride to assist eye irrigation ... . /Copper and related compounds/

IN GENERAL SOL IONIZED SALTS OF COPPER ARE MUCH MORE TOXIC THAN INSOL OR SLIGHTLY DISSOCIATED CMPD. PROBABLY THE MOST POISONOUS SALTS ARE CHLORIDE & SUBACETATE.

copper(II) chloride

Grades: technical; chemically pure; reagent /Dihydrate/

All other basic inorganic chemical manufacturing|Copper chloride (CuCl2): ACTIVE|Copper chloride: ACTIVE|AS READILY AVAILABLE FORM OF COPPER IN FEEDING TRIALS. COMPARES FAVORABLY WITH COPPER SULFATE IN CATTLE AND SWINE TRIALS.|... SALTS OF COPPER, INCLUDING THE SUBACETATE, OXYCHLORIDE, CHLORIDE AND OXIDE, HAVE FUNGICIDAL PROPERTIES AND OCCASIONALLY REPLACE THE SULFATE IN SPRAYS. ...|CONCENTRATED CUPRIC CHLORIDE SOLUTIONS ABSORB LARGE QUANTITIES OF NITROGEN GAS & HENCE ARE OF INTEREST IN POLLUTION CONTROL.|The cmpd, eg: cupric nitrate, cupric sulfate, cupric chloride, cupric acetate, showed excellent preservation of mosses and lichens, and very good preservation of ferns and grasses.

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Health Hazards -> Corrosives